PMID: 2117715Jul 1, 1990Paper

Hypothyroidism following radiotherapy for head and neck cancer

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
D A LieningD B Smith

Abstract

Hypothyroidism is not commonly considered a complication of radiotherapy for head and neck cancer. A series of 96 patients treated with radiotherapy alone or combined with surgery for head and neck cancer was retrospectively studied. All patients had radiation ports that included the thyroid gland. Hypothyroidism after radiotherapy was documented in 26% of all patients. The majority of patients had subclinical hypothyroidism manifested by elevated thyroid-stimulating hormone (TSH) levels. The incidence of hypothyroidism dramatically increased to 65% when radiotherapy was combined with surgery that included a partial thyroidectomy. In addition, we report the unusual occurrence of massive head, neck, and hypopharyngeal edema caused by severe hypothyroidism in two patients. We advocate routine monitoring of head and neck cancer patients for hypothyroidism after radiotherapy involving the thyroid gland and recommend levothyroxine replacement therapy for subclinical hypothyroidism.

References

Mar 1, 1979·Clinics in Endocrinology and Metabolism·R Hall, M F Scanlon
Jul 1, 1988·Archives of Otolaryngology--head & Neck Surgery·S W Swann, D B Blakeslee
Jul 1, 1972·The Laryngoscope·R E Murken, A J Duvall
Aug 1, 1971·The Annals of Otology, Rhinology, and Laryngology·R J Lavelle
Feb 1, 1967·Radiology·J Einhorn, G Wilkholm
Jan 1, 1982·Acta Radiologica. Oncology·J M de JongM Frölich
Feb 1, 1983·The American Journal of Medicine·M M KaplanM J Sack
May 1, 1982·Archives of Otolaryngology·M V AlexanderR L Henderson
Sep 1, 1981·The Annals of Otology, Rhinology, and Laryngology·D P Vrabec, T J Heffron
May 1, 1963·The British Journal of Radiology·A W GOOLDEN, J B DAVEY
May 8, 1965·British Medical Journal·J L MARKSON, G E FLATMAN

❮ Previous
Next ❯

Citations

Mar 1, 1992·The Annals of Otology, Rhinology, and Laryngology·W F McGuirtW M McKinney
Jun 1, 1995·Clinical Otolaryngology and Allied Sciences·M J DonnellyT P O'Dwyer
Sep 8, 2012·Thyroid : Official Journal of the American Thyroid Association·Jeffrey R GarberUNKNOWN American Association Of Clinical Endocrinologists And American Thyroid Association Taskforce On Hypothyroidism In Adults
Sep 13, 2017·Laryngoscope Investigative Otolaryngology·Marcus M MonroeMia Hashibe
Nov 20, 2019·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Deepak Rao, Saumya Shah
Jul 7, 2000·Thyroid : Official Journal of the American Thyroid Association·K SmolarzH Schicha
Oct 7, 2006·American Journal of Clinical Oncology·Anna A NorrisWilliam M Mendenhall
Jun 1, 2005·American Journal of Clinical Oncology·Allie Garcia-SerraWilliam M Mendenhall
Feb 18, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·S KumarH Griffiths
Dec 2, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Seyhan AlkanBurhan Dadaş
Dec 19, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jeffrey R GarberUNKNOWN American Association of Clinical Endocrinologists and American Thyroid Association Taskforce on Hypothyroidism in Adults
Mar 25, 2009·American Journal of Clinical Oncology·Mehmet Koc, Ilyas Capoglu
Feb 6, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·James V HennesseyUNKNOWN American College of Endocrinology (ACE)

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Issac SachmechiPaul J Kim
The Annals of Otology, Rhinology, and Laryngology
D P Vrabec, T J Heffron
Bulletin du cancer. Radiothérapie : journal de la Société française du cancer : organe de la société française de radiothérapie oncologique
G M JungA Gentine
American Family Physician
K SalmanL I Rose
Circulation Journal : Official Journal of the Japanese Circulation Society
Naoyuki TakashimaNaoharu Iwai
© 2021 Meta ULC. All rights reserved