Hypothyroidism in patients with thalassemia syndromes

Acta Haematologica
S MagroV De Santis

Abstract

Sixty transfusion-dependent thalassemic patients were studied by simultaneous measurement of circulating thyroid hormones, basal thyroid-stimulating hormone (TSH) and TSH response to thyrotropin-releasing hormone with the aim of evaluating the frequency of hypothyroidism in such patients, and the relationship between hypothyroidism and compliance with treatment and iron overload. Thyroid failure was present in 31 of the 60 patients. A correlation was found between impairment of thyroid functions, duration of chronic hypoxia and the activities of various transaminases. The results of this study emphasize the importance of early evaluation of thyroid function in thalassemic patients and suggest that anemia and hypoxia may potentiate the toxicity of iron deposition in endocrine glands.

Citations

Jan 14, 1999·British Journal of Haematology·C E JensenB Wonke
Mar 28, 2002·Thyroid : Official Journal of the American Thyroid Association·Athanasios ZervasGeorge Tolis
Mar 1, 1997·Journal of Pediatric Endocrinology & Metabolism : JPEM·L C Low
Mar 6, 2010·Journal of Endocrinological Investigation·M Delvecchio, L Cavallo
Jul 8, 1999·The New England Journal of Medicine·N F Olivieri
Feb 13, 2003·Pediatric Clinics of North America·Louise Lo, Sylvia Titi Singer
Aug 14, 2003·BMC Endocrine Disorders·Alireza Abdollah ShamshirsazBagher Larijani
Dec 1, 1994·Acta Paediatrica. Supplement·S Pantelakis
Sep 10, 2008·Annals of Saudi Medicine·Farzad NajafipourManouchehr Khoshbaten
Nov 28, 2001·Hematology·J P KushnerN F Olivieri
Jun 11, 2016·Biomedical Reports·Ahmed Al-AkhrasMarwa Zakaria

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