Hypothyroidism-induced myocardial damage and heart failure: an overlooked entity

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Mony ShuvyChaim Lotan

Abstract

Hypothyroid state may induce cardiac muscle impairment such as diastolic dysfunction and abnormal relaxation time. Advanced heart failure in hypothyroid patients has been described only in severe symptomatic cases, mostly during myxedematous coma. We describe an unusual case of asymptomatic patient with hypothyroidism who presented with severely reduced cardiac function with elevated cardiac enzymes reflecting significant myocardial injury. Comprehensive evaluation for heart failure was suggestive only for long-standing untreated hypothyroidism. Endomyocadial biopsy demonstrated unique histological findings of mucopolysaccharide accumulation attributed to hypothyroid state. Asymptomatic hypothyroidism may cause severe reduction in cardiac function accompanied with elevated cardiac enzymes. To our knowledge, this is the first description of human myocardial biopsy revealing mucopolysaccharide accumulation attributed to hypothyroid state.

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Citations

Jan 7, 2009·Heart Failure Reviews·Wolfgang Dillmann
May 20, 2009·The Journal of Emergency Medicine·Goran P Koracevic
Jul 30, 2014·Frontiers in Endocrinology·Giampaolo PapiAlfredo Pontecorvi
Dec 6, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Shunzhong S Bao, Simon J Fisher
Nov 25, 2017·Cardiology Research and Practice·Alvaro Altamirano UfionPrajwal Boddu

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