Hypothyroidism protects against free radical damage in ischemic acute renal failure

Kidney International
M S Paller

Abstract

The effect of hypothyroidism on ischemic acute renal failure was studied in rats. Ten days after thyroidectomy with parathyroid reimplantation, rats underwent right uninephrectomy followed by occlusion of the left renal artery for 60 min. Plasma creatinine was lower in thyroidectomized than control rats 24 hr after ischemia; 1.3 +/- 0.5 vs. 3.2 +/- 0.6 mg%; P less than 0.05. Twenty-four hours after ischemia, inulin clearance was higher in thyroidectomized than control animals (0.40 +/- 0.06 vs. 0.17 +/- 0.03 mliter/min; P less than 0.01), despite an initially lower inulin clearance in thyroidectomized animals (0.81 vs. 1.1 +/- 0.07 mliter/min; P less than 0.05). Administration of the antithyroid drug prophylthiouracil for 14 days also resulted in lower plasma creatinine after ischemia. Kidneys from thyroidectomized animals showed less histologic damage 24 hr after ischemia. Renal cortical content of the lipid peroxidation product malondialdehyde was increased less in thyroidectomy than control kidneys after 60 min ischemia plus 15 min reflow (0.08 +/- 0.02 vs. 0.42 +/- 0.1 nmole/mg protein; P less than 0.005). Renal cortical glutathione content was higher in thyroidectomized animals by approximately 36%, 650 +/- 46 vs. 479 +/- ...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Sep 8, 1978·Science·I Fridovich
Feb 1, 1979·Toxicology and Applied Pharmacology·J Yam, R J Roberts
Oct 19, 1977·Pflügers Archiv : European journal of physiology·H OsswaldR Kemper
Sep 1, 1978·Circulation Research·W L MillerR Rubio
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Nov 1, 1970·The Biochemical Journal·D A Hems, J T Brosnan
Apr 1, 1973·The Journal of Clinical Investigation·A I Katz, M D Lindheimer
Jun 1, 1970·The Journal of Clinical Investigation·E W Holmes, V A DiScala
Oct 1, 1984·The Journal of Clinical Investigation·M S PallerT F Ferris
Jun 1, 1984·Kidney International·N J SiegelM Kashgarian

❮ Previous
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Citations

Jul 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·K G DickmanL J Mandel
Jan 1, 1988·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·P M SutterN J Siegel
Feb 15, 2013·Biological Trace Element Research·Selmin ToplanMehmet C Akyolcu
Jan 1, 1991·Chemico-biological Interactions·T Y AwD P Jones
Jan 1, 1990·Free Radical Biology & Medicine·K Asayama, K Kato
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R BuhlR G Crystal
Nov 1, 1987·The Journal of Clinical Investigation·J M WeinbergT Rajan
Feb 1, 1990·The Journal of Clinical Investigation·L J MandelW R Jacobs
Jun 6, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Roberto Imberti, Mariapia Vairetti
Jul 9, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Hüsamettin ErdamarIlhan Yetkin
Dec 20, 2013·International Journal of Molecular Sciences·Antonio ManciniElisabetta Meucci
Dec 21, 2012·Cellular and Molecular Life Sciences : CMLS·Paola VendittiSergio Di Meo
Jun 1, 2012·TheScientificWorldJournal·Pallavi Mishra, Luna Samanta
May 11, 2000·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·K V Luong, L T Nguyen
Oct 1, 1988·Kidney International·M S Paller, B E Hedlund
Apr 24, 2012·General and Comparative Endocrinology·Srikanta JenaJagneshwar Dandapat
Aug 5, 2008·Critical Reviews in Oncology/hematology·Manuela Gago-Dominguez, Jose Esteban Castelao
Aug 24, 2006·Burns : Journal of the International Society for Burn Injuries·Göksel SenerBerrak C Yeğen
Jun 1, 2016·Drug Development Research·Mojtaba SajadianAlireza Nakhaee
Dec 6, 2016·Canadian Journal of Physiology and Pharmacology·Hongmei ZhangQing Su
May 23, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·F CostantiniA Mezzetti
Dec 13, 2005·Cytometry. Part B, Clinical Cytometry·Mita SarkarBilikere S Dwarakanath
Aug 24, 2013·Endocrine Reviews·Einav Yehuda-ShnaidmanJacob Bar-Tana
Feb 20, 2003·Archives of Biochemistry and Biophysics·Paola VendittiSergio Di Meo
Dec 24, 2004·Cell Biochemistry and Function·Sibel TaşZehra Serdar

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