Hypoventilation disproportionate to OSAS severity in children with Prader-Willi syndrome

Archives of Disease in Childhood
Francois AbelAthanasios Kaditis

Abstract

To test the hypothesis that children with Prader-Willi syndrome (PWS) and obstructive sleep apnoea syndrome (OSAS) have hypercapnia for higher proportion of total sleep time (TST) than non-syndromic children with similar obstructive apnoea-hypopnoea index (OAHI). Cross-sectional study. Two tertiary care hospitals. Patients with PWS and non-syndromic children with snoring who underwent polygraphy and were of similar age, body mass index (BMI) z-score and OAHI. The two groups were compared regarding %TST with transcutaneous CO2 (PtcCO2) >50 mm Hg. The interaction between PWS diagnosis and OSAS severity (OAHI <1 episode/h vs 1-5 episodes/h vs >5 episodes/h) regarding %TST with PtcCO2 >50 mm Hg was tested using multiple linear regression. 48 children with PWS and 92 controls were included (median age 2.3 (range 0.2-14.1) years vs 2.2 (0.3-15.1) years; BMI z-score 0.7±1.9 vs 0.8±1.7; median OAHI 0.5 (0-29.5) episodes/h vs 0.5 (0-33.9) episodes/h; p>0.05). The two groups did not differ in %TST with PtcCO2 >50 mm Hg (median 0% (0-100%) vs 0% (0-81.3%), respectively; p>0.05). However, the interaction between PWS and OSAS severity with respect to duration of hypoventilation was significant (p<0.01); the estimated mean differences of %TS...Continue Reading

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Citations

Jul 2, 2019·Journal of Paediatrics and Child Health·Jessica MackayJenny Downs
Feb 11, 2021·Sleep Medicine Reviews·Matteo CataldiLino Nobili
Feb 6, 2021·Pediatric Pulmonology·Hui-Leng Tan, Athanasios G Kaditis
Dec 7, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Jennifer SchaeferGillian M Nixon

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