Hypovitaminosis D and organ damage in patients with arterial hypertension: a multicenter double blind randomised controlled trial of cholecalciferol supplementation (HYPODD) : study design, clinical procedures and treatment protocol

High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension
Domenico RendinaPasquale Strazzullo

Abstract

At this time, good quality randomized clinical trials assessing the effects of vitamin D supplementation on cardiometabolic outcomes are lacking in the international literature. To fill this gap, the Working Group on Vitamin D and Cardiorenal Disorders established jointly by the Italian Society of Hypertension (SIIA) and the Forum in Bone and Mineral Research conceived the HYPODD study (HYPOvitaminosis D and organ Damage). HYPODD is a no-profit multicenter 12-month parallel-group double-blind placebo controlled randomized trial aiming to assess the effects of cholecalciferol supplementation on blood pressure control, antihypertensive drugs consumption and progression of target organ damage in patients with essential hypertension and 25-hydroxyvitamin D serum level lower than 20 ng/ml (vitamin D deficiency). HYPODD is coordinated by the European Society Excellence Center of Hypertension of Federico II University, Naples, and involves 12 academic institutions in Italy (Ancona, Milan, Padua, Perugia, Rome, Siena, Trieste, Turin, Udine, Varese, and Verona). The HYPODD study has been registered at the Agenzia Italiana del Farmaco-Osservatorio sulla Sperimentazione Clinica del Farmaco (AIFA-OsSC) and EUDRACT sites (n° 2012-003514-14)...Continue Reading

References

Feb 15, 2001·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·D EhlerUNKNOWN American Society of Echocardiography Sonographer Training and Education Committee
Feb 19, 2002·BMJ : British Medical Journal·Steve Meek, Francis Morris
Feb 23, 2002·BMJ : British Medical Journal·Steve Meek, Francis Morris
May 25, 2002·BMJ : British Medical Journal·June EdhouseJihad M Khalil
Apr 23, 2004·The New England Journal of Medicine·John P Bilezikian, Shonni J Silverberg
Jun 14, 2005·American Journal of Physiology. Renal Physiology·Adriana S DussoEduardo Slatopolsky
Mar 15, 2006·Mayo Clinic Proceedings·Michael F Holick
Sep 27, 2006·European Heart Journal·Stephane LaurentUNKNOWN European Network for Non-invasive Investigation of Large Arteries
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Nov 10, 2007·Endocrine Reviews·Bernadette Biondi, David S Cooper
Aug 19, 2009·Nature Reviews. Cardiology·Stefan PilzThomas R Pieber
Oct 16, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·D RendinaP Strazzullo
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickUNKNOWN Endocrine Society
Mar 24, 2012·The Journal of Clinical Endocrinology and Metabolism·Clifford J RosenChristine L Taylor
Aug 28, 2012·Atherosclerosis·Vincent M BrandenburgNikolaus Marx
Sep 22, 2012·Science·Kai Kupferschmidt
Sep 10, 2014·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Domenico RendinaPasquale Strazzullo

❮ Previous
Next ❯

Citations

Nov 18, 2015·Disease Markers·Dimitrios Papandreou, Zujaja-Tul-Noor Hamid
Feb 14, 2019·Advances in Pharmacological Sciences·Silpi ChandaKuldeep Singh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Peter MarckmannAlexandra Scholze
Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
David S ArvoldRobert J Sjoberg
© 2021 Meta ULC. All rights reserved