Hypovitaminosis D in a normal, apparently healthy urban European population

The Journal of Steroid Biochemistry and Molecular Biology
G D MacFarlaneA B Miller

Abstract

Serum 25 OH Vitamin D (25 OH D) concentrations generally vary with latitude, season, and the composition of the population studied. There is a growing recognition that rather than a seasonal specific decline in serum 25 OH Vitamin D, a significant proportion of the population may exhibit asymtomatic subclinical Vitamin D insufficiency. Vitamin D insufficiency has been described in populations at risk, such as nursing home residents and the homebound elderly. We assessed a population of normal, apparently healthy volunteers at a single European urban center for 25 OH Vitamin D sufficiency. Serum 25 OH D concentrations were determined using an automated LIAISON((R)) 25 OH Vitamin D assay. For the purposes of this study, Vitamin D insufficiency was defined as a serum 25 OH Vitamin D concentration of <15 ng/mL. Of the total population (n = 126) 34% exhibited 25 OH Vitamin D concentrations of <15 ng/ml. The mean +/- S.D. serum 25 OH Vitamin D concentration among the total, sufficient, and insufficient populations was 19.4 +/- 7.7, 23.6 +/- 6.4, and 12.1 +/- 2.3 ng/mL. From these data, we conclude that 25 OH Vitamin D insufficiency is more common than previously thought, and is not restricted to high-risk groups.

References

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Citations

Aug 13, 2013·The British Journal of Nutrition·Jennifer HilgerKristina Hoffmann
Dec 12, 2012·Archives of Osteoporosis·D A WahlB Dawson-Hughes
Mar 9, 2007·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·M NorvalJ C van der Leun
Oct 1, 2009·Photochemistry and Photobiology·Johan MoanAlina Carmen Porojnicu
Jul 20, 2004·BMJ : British Medical Journal·Gabrielle de Torrenté de la JaraBernard Favrat
Jan 18, 2011·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Laura A G Armas, Robert P Heaney
Oct 24, 2007·The Journal of Surgical Research·Todd D BeyerCarmen C Solorzano
Dec 9, 2015·Journal of Advanced Research·Wedad Z Mostafa, Rehab A Hegazy
Jan 31, 2015·Nutrition Bulletin·A Spiro, J L Buttriss
Mar 1, 2014·The European Journal of General Practice·Marie France Le GoaziouGilbert Souweine
Feb 26, 2011·The European Journal of General Practice·Marie France Le GoaziouAnne Marie Schott-Pethelaz
Jun 1, 2007·European Journal of Clinical Nutrition·B HintzpeterC Scheidt-Nave
Jul 18, 2006·The Medical Journal of Australia·Jill BensonNicole Moulding

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