PMID: 8950326Jan 1, 1996Paper

Hypoxanthine and xanthine levels in human aqueous humor from cataractous eyes

Life Sciences
G SpotoA Giacomello

Abstract

Purine nucleotide degradation products have been determined by HPLC in aqueous humor obtained during cataract surgery and from plasma of 22 patients (12 women). Uric acid, cytosine, guanosine monophosphate, uracyl, guanine, adenosine, adenosine monophosphate, thymine, adenine, inosine, cyclic guanosine monophosphate, hypoxanthine and xanthine were evaluated. Uric acid and the last two were the only compounds detectable in measurable amounts in aqueous humor and in plasma of all patients. Aqueous humor xanthine levels were not significantly different from plasma; aqueous humor hypoxanthine concentrations were lower than those of xanthine and than plasma oxypurine levels. In 8 patients, treated with allopurinol, oxypurinol concentrations in aqueous humor and in plasma were comparable suggesting that oxypurines are transported through the blood-aqueous humor barrier.

References

Jan 1, 1986·Journal of Inherited Metabolic Disease·R A HarknessI R MacFadyen
Jan 1, 1969·Annals of Internal Medicine·W N KelleyJ E Seegmiller
Nov 1, 1966·Annals of the Rheumatic Diseases·G B Elion
Jul 1, 1966·Biochemical Pharmacology·G B ElionG H Hitchings
Oct 16, 1967·JAMA : the Journal of the American Medical Association·F M RosenbloomJ E Seegmiller
Jan 1, 1980·Advances in Experimental Medicine and Biology·G B ElionW N Kelley
Jan 1, 1994·Advances in Experimental Medicine and Biology·J G PuigA Gil

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