Hypoxanthine as a graft ischemia marker stimulates catalase activity in the renal vein during reperfusion in humans

Transplantation Proceedings
Leszek DomańskiD Chlubek

Abstract

The impairment of organ function derived from ischemia-reperfusion injury is still an important problem in solid organ transplantation. Cell alterations induced by ischemia prime the tissue for subsequent damage occurring during the reperfusion phase. Purine nucleotides and oxypurines are products of adenine nucleotide degradation. Reperfusion and reoxygenation are characterized by great production of reactive oxygen species and free radicals. On the contrary, superoxide dismutase, catalase, glutathione, and glutathione peroxidase are involved in protecting against free radicals. The aim of the study was to examine the correlation between concentrations of ischemia markers (hypoxanthine or inosine) and the activity of erythrocyte superoxide dismutase, catalase, or glutathione peroxidase. The study included 40 renal transplant recipients. Before anastomosis of the kidney vessels with the recipient's iliac vessels, a "0" blood sample was taken from the iliac vein. Then, after anastomosis, the renal vein of the graft was cannulated and blood samples I, II, and III were obtained. The reperfusion of the transplanted kidney was measured with a thermovision camera ThermaCAM SC500. The plasma concentrations of hypoxanthine and inosine ...Continue Reading

References

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Citations

Oct 27, 2016·Journal of Cellular and Molecular Medicine·Hye-Myung RyuYong-Lim Kim
Oct 21, 2006·Current Opinion in Nephrology and Hypertension·David S Wishart
Nov 20, 2009·American Journal of Physiology. Renal Physiology·Geum-Sook HwangTae-Hwan Kwon
Jul 1, 2011·Clinical Pharmacology and Therapeutics·P KhatriA J Butte
Jan 15, 2016·Molecular and Cellular Biochemistry·Sunil KumarMukut Minz
Mar 14, 2018·Progress in Biophysics and Molecular Biology·Hessam Sepasi Tehrani, Ali Akbar Moosavi-Movahedi

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