Hypoxanthine-guanine phosphoribosyltransferase activity in normal and leukaemic lymphocytes

British Journal of Haematology
P Rambotti, S Davis

Abstract

The levels of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) were determined in lymphocytes from normal people and patients with chronic lymphocytic leukaemia (CLL). The HGPRT level in the total lymphocyte population from patients with CLL was lower than that from normal subjects. The HGPRT activity was higher in normal non-T cells than normal T cells. The enzyme activity in CLL B cells was lower than in CLL T cells. The HGPRT level was higher in CLL T cells than in normal T cells; these data suggest CLL T cells differ biochemically from their normal counterparts.

References

Nov 1, 1979·The Journal of Surgical Research·A M GageA A Gage
Oct 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·L A JohnsonB T Emmerson
Jul 1, 1973·Clinical Immunology and Immunopathology·Z BentwichH G Kunkel
Mar 1, 1971·American Journal of Clinical Pathology·L T YamW H Crosby

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Citations

Dec 1, 1982·American Journal of Hematology·N L Dunn, H M Maurer
Jan 1, 1985·Critical Reviews in Oncology/hematology·P Rambotti, S Davis

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