Hypoxemia and acute mountain sickness: which comes first?

High Altitude Medicine & Biology
Jack A LoeppkyR C Roach

Abstract

Hypoxemia is usually associated with acute mountain sickness (AMS), but most studies have varied in time and magnitude of altitude exposure, exercise, diet, environmental conditions, and severity of pulmonary edema. We wished to determine whether hypoxemia occurred early in subjects who developed subsequent AMS while resting at a simulated altitude of 426 mmHg (approximately 16,000 ft or 4880 m). Exposures of 51 men and women were carried out for 8 to 12 h. AMS was determined by Lake Louise (LL) and AMS-C scores near the end of exposure, with spirometry and gas exchange measured the day before (C) and after 1 (A1), 6 (A6), and last (A12) h at simulated altitude and arterial blood at C, A1, and A12. Responses of 16 subjects having the lowest AMS scores (nonAMS: mean LL=1.0, range=0-2.5) were compared with the 16 having the highest scores (+AMS: mean LL=7.4, range=5-11). Total and alveolar ventilation responses to altitude were not different between groups. +AMS had significantly lower PaO2 (4.6 mmHg) and SaO2 (4.8%) at A1 and 3.3 mmHg and 3.1% at A12. Spirometry changes were similar at A1, but at A6 and A12 reduced vital capacity (VC) and increased breathing frequency suggested interstitial pulmonary edema in +AMS. The early hyp...Continue Reading

References

Mar 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J W Severinghaus
Nov 1, 1992·Journal of Applied Physiology·A OlivenS G Kelsen
Oct 1, 1992·International Journal of Sports Medicine·C RathatP Larmignat
Jan 1, 1989·The Journal of Physiology·C T KappagodaK K Teo
Jul 1, 1969·Journal of Applied Physiology·L D Wood, A C Bryan
Dec 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·H Z BencowitzJ B West
Oct 1, 1993·Respiration Physiology·J A LoeppkyU C Luft
Apr 1, 1993·Computers and Biomedical Research, an International Journal·M F Vidal MeloU C Luft
May 1, 1993·The American Review of Respiratory Disease·C H WelshC S Houston
Jan 21, 2000·Journal of Applied Physiology·B BraunG E Butterfield
Mar 20, 2001·High Altitude Medicine & Biology·N P MasonJ S Milledge
Sep 28, 2002·Critical Care Medicine·Alex LoeckingerKarl H Lindner
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Luciano BernardiFelicia B Axelrod
Mar 13, 2003·High Altitude Medicine & Biology·Peter BärtschElke Hohenhaus
Jan 1, 1960·Journal of Applied Physiology·D G JULIANC H CRUMP
Oct 17, 2003·Clinical Science·Beth A BeidlemanMichael N Sawka
Oct 17, 2003·High Altitude Medicine & Biology·Jack A LoeppkyRobert C Roach
Sep 30, 2004·High Altitude Medicine & Biology·Martin BurtscherMartin Faulhaber
Feb 11, 2005·Journal of Applied Physiology·Peter BärtschErik R Swenson
Jul 19, 2005·Respiratory Physiology & Neurobiology·Jack A LoeppkyMarcos F Vidal Melo
Sep 2, 2006·American Journal of Respiratory and Critical Care Medicine·Christoph DehnertChristian Fink
Oct 4, 2006·Annals of Internal Medicine·Erik R Swenson
Dec 28, 2006·JAMA : the Journal of the American Medical Association·Yves AllemannChristian Seiler
Feb 27, 2007·European Journal of Applied Physiology·Gustave SavoureyCyprien Bourrilhon
Mar 31, 2007·High Altitude Medicine & Biology·Peter D WagnerCharles S Houston
Sep 7, 2007·Respiratory Physiology & Neurobiology·Wayne J E LammMichael P Hlastala
Nov 22, 2007·Sleep & Breathing = Schlaf & Atmung·M BurtscherH Gatterer
Dec 7, 2007·Sleep & Breathing = Schlaf & Atmung·Martin BurtscherMartin Faulhaber

❮ Previous
Next ❯

Citations

Nov 12, 2009·European Heart Journal·Piergiuseppe AgostoniUNKNOWN HIGHCARE Investigators
Jun 5, 2012·Wilderness & Environmental Medicine·Dale R WagnerJack P Fry
Jun 5, 2012·Wilderness & Environmental Medicine·Hang-Cheng ChenMeng-Huan Wu
Dec 31, 2009·High Altitude Medicine & Biology·Andrew M Luks
Dec 31, 2010·High Altitude Medicine & Biology·Heikki M KarinenHeikki O Tikkanen
May 19, 2010·Expert Review of Respiratory Medicine·Joshua O StreamColin K Grissom
Feb 9, 2016·Indian Journal of Clinical Biochemistry : IJCB·K P MishraS B Singh
Aug 3, 2012·Scandinavian Journal of Medicine & Science in Sports·M WilleM Burtscher
Jun 3, 2015·Sleep & Breathing = Schlaf & Atmung·Veronika LeichtfriedWolfgang Schobersberger
Mar 25, 2015·High Altitude Medicine & Biology·Dana M DiPasqualeMichael J Buono
Apr 19, 2017·High Altitude Medicine & Biology·Angus SutherlandJamie Hugo Macdonald
Jul 27, 2018·Clinical Transplantation·Maria Sanz-de la GarzaMichel White
Dec 17, 2019·Journal of Geriatric Psychiatry and Neurology·Shou LiuYu-Tao Xiang
Nov 27, 2015·Journal of Applied Physiology·Ruud Van Thienen, Peter Hespel
Dec 25, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Cemal CingiAli Guvey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Sleep & Breathing = Schlaf & Atmung
Martin BurtscherMartin Faulhaber
European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine
Michael S KoehleDarren E R Warburton
© 2021 Meta ULC. All rights reserved