PMID: 6782058Feb 1, 1981

Hypoxemia and pulmonary gas exchange during hemodialysis

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
R W PattersonS F Sullivan

Abstract

With measured values of arterial blood gas tensions, of expired respiratory gas fractions, and volume of the expired ventilation, the determinants of alveolar oxygen tension (PAO2) were used to evaluate their influence on the development of the arterial hypoxemia that occurs in spontaneously breathing patients undergoing hemodialysis using an acetate dialysate. Dialysis produced no significant changes in the alveolar-arterial O2 tension gradient (AaDO2). The extracorporeal dialyzer removed an average of 30 ml.m-2.min-1 of CO2. Accordingly the pulmonary gas exchange ratio (R) dropped from a mean predialysis value of 0.81 to 0.62 (P less than 0.001). The arterial CO2 tension remained constant throughout, whereas the minute ventilation, both total (P less than 0.01) and alveolar (P less than 0.01), decreased during dialysis. This decrease in ventilation accounts for more than 80% of the fall in PAO2. During dialysis there was a decrease (P less than 0.001) in arterial oxygen tension (PaO2), which varied among the individuals from 9 to 23% of control. During the postdialysis hour PaO2 returns to control values concomitant with increase in ventilation. The quantitative gas exchange relationships among R, alveolar ventilation, and Aa...Continue Reading

Citations

Aug 17, 1990·Klinische Wochenschrift·S GrosserH Greten
Jun 1, 1984·Biomedizinische Technik. Biomedical Engineering·H HamplM Kessel
Mar 1, 1990·Journal of the American Geriatrics Society·A T RoyJ E Morley
Jul 24, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Heather A HaugenFanny Li
Nov 1, 1982·Artificial Organs·M W Weiner

Related Concepts

Anoxemia
Carbon Dioxide
Hemodialysis
Kidney Failure, Chronic
Lung Volume Measurements
Dioxygen
Pulmonary Diffusing Capacity

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