Hypoxemic reperfusion of ischemic states: an alternative approach for the attenuation of oxidative stress mediated reperfusion injury

Journal of Biomedical Science
Marios-Konstantinos Tasoulis, Emmanuel E Douzinas

Abstract

Ischemia and reperfusion (I/R) - induced injury has been described as one of the main factors that contribute to the observed morbidity and mortality in a variety of clinical entities, including myocardial infarction, ischemic stroke, cardiac arrest and trauma. An imbalance between oxygen demand and supply, within the organ beds during ischemia, results in profound tissue hypoxia. The subsequent abrupt oxygen re-entry upon reperfusion, may lead to a burst of oxidative aggression through production of reactive oxygen species by the primed cells. The predominant role of oxidative stress in the pathophysiology of I/R mediated injury, has been well established. A number of strategies that target the attenuation of the oxidative burst have been tested both in the experimental and the clinical setting. Despite these advances, I/R injury continues to be a major problem in everyday medical practice. The aim of this paper is to review the existing literature regarding an alternative approach, termed hypoxemic reperfusion, that has exhibited promising results in the attenuation of I/R injury, both in the experimental and the clinical setting. Further research to clarify its underlying mechanisms and to assess its efficacy in the clinical...Continue Reading

References

Nov 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J BurdaJ Marsala
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Apr 1, 1987·Journal of Applied Physiology·D P YounkinM Delivoria-Papadopoulos
Sep 16, 2003·Critical Care Medicine·Emmanuel E DouzinasCharis Roussos
Nov 26, 2004·American Journal of Physiology. Heart and Circulatory Physiology·He-Ying SunZhi-Qing Zhao
Jun 9, 2006·Apoptosis : an International Journal on Programmed Cell Death·Hai-Chang WangFeng Gao
Mar 3, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Edward J HickeyRoss M Ungerleider
Sep 15, 2007·The New England Journal of Medicine·Derek M Yellon, Derek J Hausenloy
Aug 12, 2008·American Journal of Physiology. Heart and Circulatory Physiology·S Kelly AmblerLawrence D Horwitz
Feb 5, 2009·Intensive Care Medicine·Ke-Xuan LiuZhengyuan Xia
Jun 23, 2009·Cytokine·Emmanuel E DouzinasEvangelos J Giamarellos-Bourboulis
Oct 24, 2009·The Tohoku Journal of Experimental Medicine·Marios-Konstantinos TasoulisEmmanuel E Douzinas
May 25, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Mahmoud Abu-AmaraBrian R Davidson
Sep 11, 2010·The Journal of Surgical Research·Ryan K LehmannMatthew J Martin
Mar 23, 2013·Transplantation·Eline K van den AkkerFrank J M F Dor
Mar 29, 2013·European Heart Journal·Georg M FröhlichDerek J Hausenloy
Oct 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Zheqing CaiGregg L Semenza
Nov 15, 2013·The British Journal of Surgery·S O'NeillE M Harrison
Dec 4, 2013·Free Radical Biology & Medicine·Ziyan ZhangHonglian Shi
Jul 8, 2014·Oxidative Medicine and Cellular Longevity·Spyridon SavvanisKassiani Theodoraki
Jul 30, 2014·World Journal of Gastroenterology : WJG·Tao WangBo-Hua Wu
Dec 3, 2014·Archives of Cardiovascular Diseases·Caroline TouboulTheodora Bejan-Angoulvant
Jun 6, 2015·Apoptosis : an International Journal on Programmed Cell Death·YuZhen LiDanDan Song
Jul 18, 2015·World Journal of Gastroenterology : WJG·Yuan-Yuan JiWei-Na Yue

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Citations

Apr 27, 2016·Molecular Aspects of Medicine·Kelvin J A Davies
May 25, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Shogo ShimizuMotoaki Saito
Feb 27, 2016·Current Opinion in Organ Transplantation·Andrea SchlegelPhilipp Dutkowski

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Methods Mentioned

BETA
SMA
coronary artery bypass
MDA
bronchoalveolar
flow cytometry

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