PMID: 8941549Nov 1, 1996Paper

Hypoxia- and normoxia-induced reversibility of autonomic control in Andean guinea pig heart

Journal of Applied Physiology
F León-VelardeD Clark

Abstract

We herein describe the regulation of cardiac receptors in a typical high-altitude native animal. Heart rate response to isoproterenol (HRIso) (beats.min-1.mg Iso.kg-1) and atropine, the density of beta-adrenergic (beta AR) and muscarinic (M2) receptors, and the ventricular content of norepinephrine (NE) and dopamine (DA) were studied in guinea pigs (Cavia porcellus). Animals native to Lima, Peru (150 m) were studied at sea level (SL) and after 5 wk at 4,300-m altitude (SL-HA). Animals native to Rancas [Pasco, Peru (4,300 m)] were studied at high altitude (HA) and after 5 wk at SL (HA-SL). HA animals had a lower HRIso, maximum number of beta AR binding sites (Bmax), beta AR dissociation constant (Kd), NE, and DA (P < 0.05) and a higher M2 Bmax (P < 0.001) when compared with the SL group. HA-SL showed an increase of the HRIso, beta Ar Kd, and NE (P < 0.05) and a decrease of the M2 Bmax and Kd (P < 0.0001) when compared with the HA group. The present study demonstrates the differential regulation and reversibility of the autonomic control in the guinea pig heart.

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Citations

Sep 8, 2000·Bulletin of Experimental Biology and Medicine·M N ObrezchikovaV B Koshelev
Dec 22, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·F León-VelardeJ P Richalet
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R M MohanD J Paterson
Dec 5, 2013·Physiological Reports·Aurélien PichonRi-Li Ge
Sep 27, 2018·Annual Review of Physiology·Grant B McClelland, Graham R Scott
Oct 27, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·F León-VelardeD Clark
May 25, 2007·Respiratory Physiology & Neurobiology·Fabrice Favret, Jean-Paul Richalet

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