Hypoxia: A cause of acute renal failure and alteration of gastrointestinal microbial ecology

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Animesh SamantaDilip K Nandi

Abstract

Oxygen is very important to the existence of life. Oxygen deficiency, defined as hypoxia, elicits adaptive responses in cells and tissues. Lower oxygen concentration can cause the alteration of renal function, affects the maintenance of a balance of the body fluids, electrolytes, pH, and blood pressure homeostasis. Impaired fluid regulation could, in addition, contribute to the precipitation of pulmonary edema and exacerbate hypoxemia which may accelerate the progression of chronic kidney disease. In this context, the present study attempted to evaluate the association of renal injury and oxidative stress at different atmospheric pressures (1829, 3657, and 5486 m). Limited fecal analysis of experimental animals was also done to evaluate the impact of hypobaric hypoxia on the composition of dominant gastrointestinal microbiota. The study was performed on 24 male Wister strain rats and divided into four groups (C, HA-I, HA-II, and HA-III), and exposure was carried out for seven days period. In hypoxic exposure rats, plasma urea, creatinine, electrolytes and malonaldehyde level elevated and catalase and superoxide dismutase level diminished significantly compared to the controls. Increase in blood uremia profile, toxicity markers,...Continue Reading

Citations

May 26, 2021·Journal of Clinical Laboratory Analysis·Ruo Ran WangYan Kang
Jun 3, 2021·Toxins·Taku KobayashiTakashi Wada
Oct 2, 2021·Critical Reviews in Food Science and Nutrition·Yinghui LiJunling Shi

❮ Previous
Next ❯

Related Concepts

Related Feeds