PMID: 9555102May 23, 1998Paper

Hypoxia and contractions do not utilize the same signaling mechanism in stimulating skeletal muscle glucose transport

Biochimica Et Biophysica Acta
J F WojtaszewskiErik A Richter

Abstract

We have investigated whether hypoxia and muscle contractions stimulate glucose transport in perfused rat muscle to the same extent, additively and with the same sensitivity to the microbial products calphostin C and wortmannin. Hindlimb glucose uptake increased gradually from 3.4+/-0.5 to a maximal level of 12.7+/-0.6 micromol g-1 h-1 (n=11) after 50 min of hypoxia. Compared with hypoxia, the effect of maximal electrical stimulation of the sciatic nerve on muscle glucose uptake was more than two-fold higher (27+/-2 micromol g-1 h-1 (n=14)). This was due to a higher contraction- vs. hypoxia-induced glucose transport rate in oxidative fibers. The stimulatory effect of hypoxia and electrical stimulation was not additive. Contraction-induced muscle glucose transport was inhibitable by both calphostin C and wortmannin in the micromolar range, whereas the effect of hypoxia was totally insensitive to these drugs. Our data suggest that diacylglycerol/phorbol ester-sensitive protein kinase C is involved in stimulation of muscle glucose transport by contractions and that in contrast to the prevailing concept, hypoxia and contractions do not stimulate muscle glucose transport by the same signaling mechanism.

References

Apr 1, 1991·Journal of Applied Physiology·G D CarteeJ O Holloszy
Mar 15, 1989·Biochemical and Biophysical Research Communications·E KobayashiT Tamaoki
Jul 1, 1986·The American Journal of Physiology·M Shiota, T Sugano
Mar 1, 1985·The American Journal of Physiology·L L SprietN L Jones
Jan 1, 1982·The American Journal of Physiology·T Ohhashi, T Azuma
Jul 1, 1994·Journal of Applied Physiology·K A DoraM G Clark

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Citations

Jul 10, 2013·The Journal of Physiological Sciences : JPS·Keiichi KoshinakaKentaro Kawanaka
Jun 26, 2001·Acta Physiologica Scandinavica·J IhlemannH Galbo
Jun 17, 2006·The Journal of Physiology·Marie E SandströmAbram Katz
Jul 27, 2010·Journal of Cellular Physiology·Wenyan NiuAmira Klip
Dec 18, 2004·The Journal of Physiology·Adam J RoseMark Hargreaves
Nov 4, 2016·Nature Reviews. Endocrinology·Lykke SylowThomas E Jensen
Jan 6, 2005·The Japanese Journal of Physiology·Shih-Wei ChouChia-Hua Kuo
Mar 29, 2018·Sports Medicine - Open·Nicola SponsielloAlessandro Marroni
Aug 6, 2004·The Proceedings of the Nutrition Society·Erik A RichterJørgen F P Wojtaszewski
Jul 19, 2005·Physiology·Adam J Rose, Erik A Richter
Jul 4, 2003·Medicine and Science in Sports and Exercise·Kirsten A BurgomasterMartin J Gibala
Feb 13, 2015·Endocrine Reviews·Orison O WoolcottRichard N Bergman
Nov 4, 2006·Journal of Applied Physiology·Abram Katz
May 22, 2009·American Journal of Physiology. Endocrinology and Metabolism·Thomas E JensenErik A Richter
Jan 21, 2010·Physiological Reviews·Gary D LopaschukWilliam C Stanley
Aug 1, 2013·Physiological Reviews·Erik A Richter, Mark Hargreaves
Jun 5, 2014·American Journal of Physiology. Endocrinology and Metabolism·Q LiW Niu
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Y IdoJ R Williamson
Jun 19, 2002·Journal of Applied Physiology·Frank W BoothEspen E Spangenburg
Jul 17, 2003·Acta Physiologica Scandinavica·E A RichterJ F P Wojtaszewski
Aug 13, 1999·The American Journal of Physiology·J IhlemannH Galbo
May 18, 2001·Journal of Applied Physiology·T L Clanton, P F Klawitter
Jul 23, 1999·Medicine and Science in Sports and Exercise·J A KovalL J Mandarino
Jun 10, 2011·American Journal of Physiology. Endocrinology and Metabolism·Boubacar BenzianeAlexander V Chibalin
Oct 27, 2020·American Journal of Physiology. Endocrinology and Metabolism·Estelle De GrooteLouise Deldicque
Jul 13, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J Z ZhangF Ismail-Beigi

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