Hypoxia and hypoxia signaling in tissue repair and fibrosis

International Review of Cell and Molecular Biology
Zerina LokmicIan A Darby

Abstract

Following injury, vascular damage results in the loss of perfusion and consequent low oxygen tension (hypoxia) which may be exacerbated by a rapid influx of inflammatory and mesenchymal cells with high metabolic demands for oxygen. Changes in systemic and cellular oxygen concentrations induce tightly regulated response pathways that attempt to restore oxygen supply to cells and modulate cell function in hypoxic conditions. Most of these responses occur through the induction of the transcription factor hypoxia-inducible factor-1 (HIF-1) which regulates many processes needed for tissue repair during ischemia in the damaged tissue. HIF-1 transcriptionally upregulates expression of metabolic proteins (GLUT-1), adhesion proteins (integrins), soluble growth factors (TGF-β and VEGF), and extracellular matrix components (type I collagen and fibronectin), which enhance the repair process. For these reasons, HIF-1 is viewed as a positive regulator of wound healing and a potential regulator of organ repair and tissue fibrosis. Understanding the complex role of hypoxia in the loss of function in scarring tissues and biology of chronic wound, and organ repair will aid in the development of pharmaceutical agents that can redress the detrimen...Continue Reading

Citations

Jun 27, 2013·Molecular and Cellular Biology·Joanna KaluckaBen Wielockx
Nov 2, 2012·Fibrogenesis & Tissue Repair·Michael P Czubryt
May 8, 2014·Advances in Wound Care·Wan Xing HongMichael T Longaker
Dec 11, 2014·Advances in Wound Care·Leeni KoivistoHannu Larjava
Apr 2, 2014·BioMed Research International·Silvana Lorena Della PennaBelisario Enrique Fernández
Jan 1, 2013·Cell Adhesion & Migration·Lívia C A RibeiroIracilda Z Carlos
May 23, 2015·Stem Cells International·Marina Marçola, Camila Eleuterio Rodrigues
Sep 10, 2014·Scientific Reports·Xupin JiangYuesheng Huang
Oct 27, 2016·Experimental Dermatology·Junhui ZhangYuesheng Huang
Mar 19, 2015·International Journal of Cancer. Journal International Du Cancer·Kuppusamy Balamurugan
Nov 5, 2014·International Journal of Molecular Sciences·Tessa D NautaPieter Koolwijk
May 23, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Dongdong TiWeidong Han
Apr 19, 2017·Cell Death Discovery·Jaymin J KathiriyaVrushank Davé
Sep 21, 2013·Experimental Biology and Medicine·Hui XieShan Gao
Feb 21, 2014·Journal of Dental Research·P-C ChangC-C Chen
Apr 15, 2016·Journal of Clinical Medicine·Sonsoles Piera-VelazquezSergio A Jimenez
Oct 19, 2017·International Journal of Molecular Sciences·Dominik André-LévigneBrigitte Pittet-Cuénod
Jan 20, 2018·American Journal of Physiology. Cell Physiology·Camilo Riquelme-GuzmánEnrique Brandan
Jun 23, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sarit AnaviOren Tirosh
Jul 19, 2017·Antioxidants & Redox Signaling·David Labrousse-AriasMaría J Calzada
Jan 9, 2018·Annals of Plastic Surgery·Anna A BorovikovaAlan David Widgerow
Aug 31, 2017·Nature Reviews. Gastroenterology & Hepatology·Sophie Van WeldenPieter Hindryckx
Jun 25, 2014·Molecules and Cells·Robin J RuthenborgJung-Whan Kim
Dec 8, 2017·Physiology·Lucas R SmithDennis E Discher
Aug 15, 2013·Current Opinion in Lipidology·Elke MarschMat J A P Daemen
Aug 10, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Idit MatotRinat Abramovitch
Jan 29, 2016·Plastic and Reconstructive Surgery·Ping XieThomas A Mustoe
Dec 9, 2015·European Journal of Immunology·Evanna L Mills, Luke A O'Neill
Sep 18, 2020·Advanced Healthcare Materials·Prachi DhavalikarElizabeth Cosgriff-Hernandez
Apr 3, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Márcio V RamosIngrid Samantha T de Figueiredo
Apr 18, 2019·Burns and Trauma·Sho Yamakawa, Kenji Hayashida

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
Clemens A K Lange, James W B Bainbridge
Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
N Borkakoti
© 2021 Meta ULC. All rights reserved