Hypoxia as a cause of treatment failure in non-small cell carcinoma of the lung

Seminars in Radiation Oncology
Odd Terje Brustugun

Abstract

Hypoxia is an important factor in tumor biology and is both a predictive and a prognostic factor in non-small cell lung cancer. The negative effect of low oxygenation on radiation therapy effect has been known for decades, but more recent research has emphasized that hypoxia also has a profound effect on a tumor's aggression and metastatic propensity. In this review, current knowledge on both these aspects of treatment failure in NSCLC due to hypoxia has been discussed, along with a presentation of modern methods for hypoxia measurement and current therapeutical interventions to circumvent the negative effect of hypoxia on treatment results.

References

Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
Nov 30, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J BernierM Piérart
Jun 6, 2000·International Journal of Radiation Oncology, Biology, Physics·C C LingJ A Koutcher
Feb 22, 2001·Journal of the National Cancer Institute·M Höckel, P Vaupel
Apr 15, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Farrokh DehdashtiBarry A Siegel
May 17, 2003·Science·Monica Garcia-BarrosRichard Kolesnick
Jun 2, 2004·Nature Reviews. Cancer·J Martin Brown, William R Wilson
Dec 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen K WilliamsonUNKNOWN Southwest Oncology Group Trial S0003
Mar 15, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Quynh-Thu LeAmato J Giaccia
Apr 28, 2006·Nature·Janine T ErlerAmato J Giaccia
Apr 27, 2007·Cancer Metastasis Reviews·Richard Sullivan, Charles H Graham
Jun 1, 2007·Antioxidants & Redox Signaling·Peter VaupelArnulf Mayer
Jul 19, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hiroshi OnishiTsutomu Araki
Jul 3, 2007·Cancer Metastasis Reviews·Debbie Liao, Randall S Johnson
Dec 31, 2008·Seminars in Cancer Biology·Gregg L Semenza
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Quynh-Thu X LeDavid R Gandara
Oct 21, 2009·Journal of Cellular and Molecular Medicine·Adrian M JubbAdrian L Harris
Jan 20, 2010·Journal of Cellular and Molecular Medicine·Yi Wang, Michael Ohh
May 4, 2010·Trends in Molecular Medicine·Xin HuangAmato J Giaccia
Sep 14, 2010·International Journal of Radiation Oncology, Biology, Physics·J Martin BrownBilly W Loo
Sep 22, 2010·Expert Opinion on Therapeutic Targets·Autumn L JacksonWilliam Y Kim
Apr 28, 2011·Cancer·May-Lin WilgusCharles A Powell
Jun 2, 2011·Nature Reviews. Clinical Oncology·Katrien De BockPeter Carmeliet
Aug 3, 2011·The International Journal of Biochemistry & Cell Biology·Athanasios KarapetsasAlex Galanis
Nov 22, 2011·International Journal of Radiation Oncology, Biology, Physics·Xiao-Dong JiangJin-Ming Yu
Jan 25, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tien HoangDavid H Johnson
May 9, 2012·The EMBO Journal·Samantha N GreerMichael Ohh
Oct 17, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tineke W H MeijerJohan Bussink
Nov 13, 2012·Cancer Biotherapy & Radiopharmaceuticals·Ling WeiLi-Yan Lv
Nov 15, 2012·Nature Reviews. Clinical Oncology·Michael R HorsmanJens Overgaard
Mar 22, 2013·Biochemical Society Transactions·Colin R Lenihan, Cormac T Taylor
Jun 22, 2013·Physics in Medicine and Biology·J JeongJ O Deasy
Jul 4, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amanda EustaceCatharine M L West
Jul 23, 2013·Journal of Medical Imaging and Radiation Oncology·Mateya E TrinkausRodney J Hicks

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Citations

Feb 19, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Adam M HirstDeborah O'Connell
Sep 20, 2017·Journal of the National Cancer Institute·Ahmed SalemCorinne Faivre-Finn
Apr 7, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·H LiG Li
Nov 13, 2020·Chemico-biological Interactions·Justyna KutkowskaAndrzej Rapak
May 23, 2020·Cancer Letters·Qiuxia XiongYongbin Chen
May 10, 2021·Journal of Experimental & Clinical Cancer Research : CR·Simona D'AguannoAntonietta Moramarco
Apr 15, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Limei YinYou Lu

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