Hypoxia-based strategies for regenerative dentistry-Views from the different dental fields

Archives of Oral Biology
Anna Sonja MüllerHermann Agis

Abstract

The understanding of the cell biological processes underlying development and regeneration of oral tissues leads to novel regenerative approaches. Over the past years, knowledge on key roles of the hypoxia-based response has become more profound. Based on these findings, novel regenerative approaches for dentistry are emerging, which target cellular oxygen sensors. These approaches include hypoxia pre-conditioning and pharmacologically simulated hypoxia. The increase in studies on hypoxia and hypoxia-based strategies in regenerative dentistry highlights the growing attention to hypoxia's role in regeneration and its underlying biology, as well as its application in a therapeutic setting. In this narrative review, we present the current knowledge on the role of hypoxia in oral tissues and review the proposed hypoxia-based approaches in different fields of dentistry, including endodontics, orthodontics, periodontics, and oral surgery.

References

Oct 6, 2012·Journal of Tissue Engineering and Regenerative Medicine·Wolfgang HolnthonerHeinz Redl

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Citations

Jun 14, 2018·Brazilian Dental Journal·Jardel Francisco Mazzi-ChavesManoel Damião Sousa-Neto
Mar 21, 2019·Journal of Periodontal Research·Klara JanjićHermann Agis
Feb 15, 2019·Journal of Biomaterials Applications·Anna Sonja MüllerHermann Agis
May 23, 2019·Clinical Oral Investigations·Gunpreet OberoiHermann Agis
Dec 15, 2018·Journal of Periodontology·Klara JanjićHermann Agis
Feb 29, 2020·International Journal of Nanomedicine·Alan Is MoraisAnderson O Lobo
Jun 27, 2020·In Vitro Cellular & Developmental Biology. Animal·Yuko Hara-SaitoKenji Izumi
Dec 26, 2018·BioMed Research International·Anna Sonja MüllerHermann Agis
Feb 18, 2019·Journal of Endodontics·Athina Maria MavridouPaul Lambrechts

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