Hypoxia Challenge Testing in Neonates for Fitness to Fly

Pediatrics
Susanne Vetter-LaracyJoan Figuerola

Abstract

Preflight hypoxia challenge testing (HCT) in a body plethysmograph has previously been done only on infants >3 months of corrected gestational age (CGA). This study aims to determine the earliest fit-to-fly age by testing neonates <1 week old. A prospective observational study was carried out on 3 groups of infants: healthy term infants ≤7 days old, preterm infants (≥34 weeks CGA) 2 to 3 days before discharge, and preterm infants with bronchopulmonary dysplasia (BPD). HCT was conducted using a body plethysmograph with a 15% fraction of inspired oxygen. The oxygen saturation (Spo2) test fail point was <85%. Twenty-four term (mean CGA 40 weeks), 62 preterm (37 weeks), and 23 preterm with BPD (39.5 weeks) infants were tested. One term infant (4.2%) and 12 preterm infants without BPD (19.4%) failed. Sixteen (69.3%) preterm infants with BPD failed (P < .001), with a median drop in Spo2 of 16%. At 39 weeks CGA, neither preterm infants without BPD nor term infants had an Spo2 <85%. However, 7 of 12 term infants with BPD failed the HCT. Term and preterm infants without BPD born at >39 weeks CGA do not appear to be likely to desaturate during a preflight HCT and so can be deemed fit to fly according to current British Thoracic Society G...Continue Reading

References

May 1, 1991·Archives of Disease in Childhood·V A StebbensD P Southall
May 1, 1991·Archives of Disease in Childhood·C F PoetsD P Southall
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·A H Jobe, E Bancalari
Mar 30, 2002·Thorax·UNKNOWN British Thoracic Society Standards of Care Committee
Apr 26, 2002·Pediatric Emergency Care·Andy P LeeNatalie L Relles
Apr 23, 2004·Archives of Disease in Childhood·M P Samuels
Mar 3, 2007·Thorax·G L HallS M Stick
Jul 6, 2007·The New England Journal of Medicine·J Michael MuhmAleksandra McMullen
Oct 2, 2007·Early Human Development·Cara Bossley, Ian M Balfour-Lynn
Feb 21, 2008·Archives of Disease in Childhood·C Bossley, I M Balfour-Lynn
Jul 26, 2011·Archives of Disease in Childhood. Fetal and Neonatal Edition·C J BossleyI M Balfour-Lynn
Oct 4, 2011·Thorax·S AhmedzaiUNKNOWN British Thoracic Society Standards of Care Committee
Jul 3, 2013·Archives of Disease in Childhood·Helene Elgaard KobbernagelBirgitte Hanel
Jul 23, 2013·Thorax·Mansi KhannaGraham L Hall
Oct 16, 2014·The New England Journal of Medicine·Ruth M LöllgenAndrew Berry

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Citations

Feb 27, 2018·European Journal of Pediatrics·Joël IsraëlsMarc van Heerde
Nov 25, 2020·Pediatric Clinics of North America·Nelson VillcaAlexandra Heath-Freudenthal
Apr 3, 2021·Pediatrics in Review·Hiba ChehabJohn C Christenson

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