Hypoxia-driven epigenetic regulation in cancer progression: A focus on histone methylation and its modifying enzymes

Cancer Letters
Iljin Kim, Jong-Wan Park

Abstract

The mechanism underlying hypoxia-driven chromatin remodeling is a long-lasting question. For the last two decades, this question has been resolved in part. It is now widely agreed that hypoxia dynamically changes the methylation status of histones to control gene expression. Hypoxia-inducible factor (HIF) plays a central role in cellular responses to hypoxia through transcriptional activation of numerous genes. At least in part, the hypoxic regulation of histone methylation is attributed to the HIF-mediated expression of histone modifying enzymes. Protein hydroxylation and histone demethylation have emerged as the oxygen sensing processes because they are catalyzed by a family of 2-oxoglutarate (2OG)-dependent dioxygenases whose activities depend upon the ambient oxygen level. Recently, it has been extensively investigated that the 2OG dioxygenases oxygen-dependently regulate histone methylation. Nowadays, the hypoxic change in the histone methylation status is regarded as an important event to drive malignant behaviors of cancer cells. In this review, we introduced and summarized the cellular processes that govern hypoxia-driven regulation of histone methylation in the context of cancer biology. We also discussed the emerging ...Continue Reading

References

Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
Dec 28, 1999·Annual Review of Cell and Developmental Biology·G L Semenza
Feb 22, 2001·Journal of the National Cancer Institute·M Höckel, P Vaupel
Feb 2, 2002·Science·David LandoMurray L Whitelaw
Apr 3, 2003·Journal of the National Cancer Institute·Eun-Jin YeoJong-Wan Park
Sep 18, 2003·Nature Reviews. Cancer·Gregg L Semenza
Dec 10, 2003·Cancer Science·Shinae Kizaka-KondohMasahiro Hiraoka
Jul 13, 2005·Mutation Research·Max CostaThomas Kluz
Sep 21, 2006·Nature Reviews. Genetics·Robert J KloseYi Zhang
Sep 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Matthew E CockmanPeter J Ratcliffe
Oct 20, 2007·Science·Bingsheng ChangRichard K Bruick
Dec 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yang XiangCharlie Degui Chen
Jan 19, 2008·Cell Death and Differentiation·K Lisy, D J Peet
Feb 26, 2008·Mutation Research·Amber Buescher JohnsonMichelle Craig Barton
May 24, 2008·Molecular Cell·William G Kaelin, Peter J Ratcliffe
Jun 10, 2008·Biochemical and Biophysical Research Communications·Sven WellmannChristoph Bührer
Aug 21, 2008·The Biochemical Journal·Patrick J PollardPeter J Ratcliffe
Nov 6, 2008·The Journal of Biological Chemistry·Sophie BeyerPeter Staller
Feb 17, 2009·Current Oncology Reports·C Lance Cowey, W Kimryn Rathmell
Mar 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Xiaobo XiaAndrew L Kung
Oct 23, 2009·Annals of the New York Academy of Sciences·Jun YangAdrian L Harris
Sep 9, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mamoru UemuraMasaki Mori
Dec 9, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yoon-Mi LeeJong-Wan Park
Apr 19, 2011·Genes & Development·Yoichi Shinkai, Makoto Tachibana
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jason S LeeSung Hee Baek
Aug 17, 2011·International Journal of Molecular Sciences·Joel I Perez-PerriPablo Wappner
Apr 3, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael MilosevicRobert Bristow

❮ Previous
Next ❯

Citations

Oct 30, 2020·Cells·Claudia Geismann, Alexander Arlt
Oct 29, 2020·Journal of Experimental & Clinical Cancer Research : CR·Tiansheng LiYongguang Tao
Jun 15, 2021·Frontiers in Physiology·Kathy PhamErica C Heinrich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.