PMID: 2507832Jan 1, 1989Paper

Hypoxia increases plasma glutathione disulfide in rats

Lung
S W ChangN F Voelkel

Abstract

We tested the hypothesis that hypoxia causes cellular oxidative stress by measuring plasma concentrations of glutathione disulfide (GSSG) in rats exposed to acute and subacute hypoxia. In awake, unanesthetized, catheter-implanted rats, exposure to 8% O2 for 10 min caused pulmonary vasoconstriction and increased plasma GSSG. This increase in plasma GSSG was reversible upon re-exposure to room air. In another group of rats exposed to 48 hours of hypobaric hypoxia (Pb 450 mmHg, equivalent to about 14,500 feet altitude), plasma GSSG, but not total glutathione, was significantly increased over control values (2.83 +/- 0.24 vs 1.84 +/- 0.14 nmol/ml, p less than 0.05). While lung tissue GSSG in high altitude-exposed rats were somewhat higher than in controls (17.4 +/- 7.0 vs 11.9 +/- 3.6 nmol/g wet lung wt.), the difference was not statistically significant. Treatment of the rats with a radical scavenger, DMSO, before altitude exposure, blocked the increase in plasma GSSG (1.86 +/- 0.16 nmol/ml). We conclude that both acute and subacute hypoxia increase plasma GSSG in rats and speculate that hypoxia induces cellular oxidative stress in vivo.

References

Jul 4, 1986·JAMA : the Journal of the American Medical Association·R B SchoeneT R Martin
Jul 1, 1988·Journal of Applied Physiology·S W ChangN F Voelkel
Dec 1, 1988·The Journal of Clinical Investigation·T J StelznerJ V Weil
May 1, 1987·The Journal of Clinical Investigation·S W ChangN F Voelkel
Jan 1, 1987·Journal of Applied Physiology·S G JenkinsonK H Johnson
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Nov 1, 1956·Journal of Applied Physiology·A CANEPAT VELASQUEZ

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Citations

Jul 1, 1993·Biotechnology and Bioengineering·A A LinW M Miller
Jan 1, 1991·Free Radical Biology & Medicine·W A Pryor, S S Godber
Jul 1, 1994·Free Radical Biology & Medicine·J P Kehrer, L G Lund
Oct 1, 1992·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·A Reuter, W Klinger
Aug 28, 2003·Clinical and Experimental Pharmacology & Physiology·Y HitomiH Ohno
Aug 9, 2012·Antioxidants & Redox Signaling·Norbert F VoelkelRamesh Natarajan
Apr 10, 2004·High Altitude Medicine & Biology·J Ashley JeffersonAbdias Hurtado
Dec 15, 2005·High Altitude Medicine & Biology·Anjana G VijNarinder K Satija
Nov 13, 2013·Toxicology and Applied Pharmacology·Samir A SalamaAdel E EL-Tarras
May 26, 2017·International Journal of Molecular Sciences·Ming Wai HungMan Lung Fung
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P MøllerN V Olsen
Aug 29, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Frantisek KolárJan Herget
Nov 7, 2020·International Journal of Biometeorology·Priya GaurPraveen Vats

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