Hypoxia-induced alternative splicing: the 11th Hallmark of Cancer.

Journal of Experimental & Clinical Cancer Research : CR
Antonietta Rosella FarinaAndrew Reay Mackay

Abstract

Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and progression. In this review, we update currents concepts of hypoxia-induced alternative splicing and how it influences tumour biology. Following brief descriptions of tumour-associated hypoxia and the pre-mRNA splicing process, we review the many ways hypoxia regulates alternative splicing and how hypoxia-induced alternative splicing impacts each individual hallmark of cancer. Hypoxia-induced alternative splicing integrates chemical and cellular tumour microenvironments, underpins continuous adaptation of the tumour cellular microenvironment responsible for metastatic progression and plays clear roles in oncogene activation and autonomous tumour growth, tumor suppressor inactivation, tumour cell immortalization, angiogenesis, tumour cell evasion of programmed cell death and the anti-tumour immune response, a tumour-promoting inflammatory response, adaptive metabolic re-programming, epithelial to mesenchymal transition, invasion and genetic instability, all of which combine to promote metastatic disease. The impressive number of hypoxia-induced alternative spliced protein isoforms that characterize tumour progression, classifies hypoxia-ind...Continue Reading

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Citations

Aug 12, 2020·Journal of Experimental & Clinical Cancer Research : CR·Rosamaria LappanoMarcello Maggiolini
Sep 27, 2020·International Journal of Molecular Sciences·Aldona Kasprzak, Witold Szaflarski
Dec 4, 2020·Biomolecules·Pierluigi ScaliaStephen J Williams
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Jan 12, 2021·Journal of Experimental & Clinical Cancer Research : CR·Muhlis AkmanChiara Riganti
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Methods Mentioned

BETA
ISS
nuclear translocation
GTPase
protein-folding
protein folding
xenograft
modified
antisense oligonucleotides

Clinical Trials Mentioned

NCT03355066

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