Hypoxia-induced fibroblast growth factor 11 stimulates capillary-like endothelial tube formation.

Oncology Reports
Jimin YangSae-Won Lee

Abstract

Low oxygen or hypoxia can be observed in the central region of solid tumors. Hypoxia is a strong stimulus for new blood vessel formation or angiogenesis, which is essential for tumor growth and progression. Fibroblast growth factor 11 (FGF11) is an intracellular non-secretory FGF whose function has not yet been fully characterized. In the present study, we demonstrated that FGF11 expression is upregulated under hypoxic conditions in human umbilical vein endothelial cells (HUVECs). FGF11 overexpression stimulated capillary-like tube formation, yet did not affect cell migration. Notably, FGF11 markedly increased the levels of tight junction proteins including occludin, zonula occludens-1 (ZO-1) and claudin-5 in HUVECs. The FGF11 promoter contains hypoxia response elements (HREs), and hypoxia-inducible factor-1 (HIF-1) binds to HREs to activate hypoxia-related genes. We demonstrated that hypoxia or HIF-1 expression under normoxic conditions increased the luciferase activity driven by the FGF11 promoter. However, deletion of the HREs from the FGF11 promoter rendered reporter gene activity unresponsive to hypoxia or HIF-1. Taken together, we propose that FGF11 may be involved in the stabilization of capillary-like tube structures as...Continue Reading

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Citations

Sep 24, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hongyu ShenJinhai Tang
Jun 20, 2020·Tissue Barriers·Mariana M CastroMariana Machado-Neves
Jun 17, 2020·Journal of Experimental & Clinical Cancer Research : CR·Antonietta Rosella FarinaAndrew Reay Mackay
Dec 28, 2016·FEBS Letters·Kyeong Won LeeJae-Yeon Jeong
Jan 12, 2017·Scientific Reports·Kiwoong NamJae-Yeon Jeong
Jul 6, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Min Ah HanSeung Jin Lee

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