Hypoxia-induced lncRNA PDIA3P1 promotes mesenchymal transition via sponging of miR-124-3p in glioma.

Cell Death & Disease
Shaobo WangGang Li

Abstract

Hypoxia is a critical factor in the malignant progression of glioma, especially for the highly-invasive mesenchymal (MES) subtype. But the detailed mechanisms in hypoxia-induced glioma MES transition remain elusive. Pseudogenes, once considered to be non-functional relics of evolution, are emerging as a critical factor in human tumorigenesis and progression. Here, we investigated the clinical significance, biological function, and mechanisms of protein disulfide isomerase family A member 3 pseudogene 1 (PDIA3P1) in hypoxia-induced glioma MES transition. In this study, we found that PDIA3P1 expression was closely related to tumor degree, transcriptome subtype, and prognosis in glioma patients. Enrichment analysis found that high PDIA3P1 expression was associated with epithelial-mesenchymal transition, extracellular matrix (ECM) disassembly, and angiogenesis. In vitro study revealed that overexpression of PDIA3P1 enhanced the migration and invasion capacity of glioma cells, while knockdown of PDIA3P1 induced the opposite effect. Further studies revealed that PDIA3P1 functions as a ceRNA, sponging miR-124-3p to modulate RELA expression and activate the downstream NF-κB pathway, thus promoting the MES transition of glioma cells. In...Continue Reading

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Citations

Nov 10, 2020·Frontiers in Immunology·Chanan MeydanHermona Soreq
Jan 8, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardMohammad Taheri
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Jun 29, 2021·Frontiers in Oncology·Jie QinXiangqi Meng
Sep 18, 2021·Journal of Cellular Physiology·Garima Yadav, Ritu Kulshreshtha

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Datasets Mentioned

BETA
GSE45301

Methods Mentioned

BETA
PCR
transfection
Assay
pulldown
pull-down
immunoprecipitation
xenograft
Fluorescence
ChIP
electrophoresis

Software Mentioned

microT
GSEA
DESeq2
DAVID
R
GraphPad Prism
ESTIMATE
Starbase
CDS

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