Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirus.

Blood
David A DavisRobert Yarchoan

Abstract

There is substantial evidence that Kaposi sarcoma-associated herpesvirus (KSHV) plays an important role in the pathogenesis of all forms of Kaposi sarcoma (KS). It has been noted that KS commonly occurs in locations, such as the feet, where tissue may be poorly oxygenated. On the basis of this observation, the potential role of hypoxia in the reactivation of KSHV replication was explored by studying 2 KSHV-infected primary effusion lymphoma B-cell lines (BC-3 and BCBL-1) latently infected with KSHV. Acute and chronic exposure of these cells to hypoxia (1% O(2)) induced KSHV lytic replication, as indicated by an increase in intracellular lytic protein expression and detection of virus in cell supernatants by Western immunoblotting. In addition, hypoxia increased the levels of secreted viral interleukin-6. Moreover, hypoxia enhanced the lytic replication initiated by the viral inducer 12-O-tetradecanoylphorbol-13-acetate. Desferoxamine and cobalt chloride, 2 compounds that increase the intracellular levels of hypoxia-inducible factor 1, were also able to induce KSHV lytic replication. These studies suggest that hypoxia is an inducer of KSHV replication. This process may play an important role in the pathogenesis of KS.

References

Dec 1, 1979·Journal of Surgical Oncology·Y Laor, R A Schwartz
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S A MilesT Kishimoto
Jun 1, 1990·Journal of the American Academy of Dermatology·A E Friedman-Kien, B R Saltzman
Jan 1, 1990·Dermatologica·R Friedman-BirnbaumI Katz
Jan 1, 1984·Annals of the New York Academy of Sciences·D L LongoJ Jacob
May 4, 1995·The New England Journal of Medicine·E CesarmanD M Knowles
Jan 1, 1997·Journal of Virology·F NeipelB Fleckenstein
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·R MasoodP S Gill
Apr 3, 1997·The New England Journal of Medicine·C S RabkinZ Zhuang
May 1, 1997·The Journal of Infectious Diseases·D A DavisR Yarchoan
Mar 1, 1997·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·D T UbbinkM J Jacobs
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·N DupinC Boshoff
Jun 29, 1999·Advances in Virus Research·R SaridP S Moore
Aug 24, 1999·Cell·G L Semenza
Dec 22, 1999·Biochemical and Biophysical Research Communications·D E RichardJ Pouysségur
Dec 28, 1999·Annual Review of Cell and Developmental Biology·G L Semenza
Feb 19, 2000·Biochemical and Biophysical Research Communications·S W LeeK W Kim
Apr 6, 2000·Journal of Applied Physiology·G L Semenza
Apr 6, 2000·The New England Journal of Medicine·K Antman, Y Chang

❮ Previous
Next ❯

Citations

Jul 2, 2011·Journal of Neuro-oncology·Alexander KofmanRoger Abounader
Jan 15, 2003·Current Infectious Disease Reports·Pallavi P. KumarRobert Yarchoan
Mar 12, 2005·Journal of the American Academy of Dermatology·Guan-Qing WangHong-Duo Chen
Jul 16, 2002·Pathologie-biologie·S Pillet, F Morinet
Aug 26, 2010·Nature Reviews. Nephrology·Inés Rama, Josep M Grinyó
Sep 6, 2002·The New England Journal of Medicine·Robert Yarchoan, David A Davis
Aug 4, 2004·The Journal of Experimental Medicine·Britt Glaunsinger, Don Ganem
Dec 8, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Xiaohui BiBetsy J Barnes
Jul 20, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Shuhei Sakakibara, Giovanna Tosato
Nov 17, 2006·Journal of Virology·Yoshihiro IzumiyaHsing-Jien Kung
Oct 29, 2005·Journal of Virology·Lei Chen, Michael Lagunoff
Jun 10, 2003·Microbiology and Molecular Biology Reviews : MMBR·Lyubomir A DourmishevDavid M Lukac
Jun 1, 2011·Advances in Virology·Fengchun YeShou-Jiang Gao
Dec 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lesley A AndersonJames J Goedert
Nov 28, 2013·PLoS Pathogens·Qiliang CaiErle S Robertson
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Vladimir Majerciak, Zhi-Ming Zheng
Aug 15, 2013·Cancer Letters·Scott A Read, Mark W Douglas
May 17, 2013·Future Virology·Sergei NekhaiSubhash Dhawan
Jun 9, 2005·Critical Reviews in Clinical Laboratory Sciences·Adina CohenRonit Sarid

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.