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Hypoxia induces transcriptional and translational downregulation of the type I interferon (IFN) pathway in multiple cancer cell types

bioRxiv

Jul 25, 2019

Ana MiarAdrian L. Harris

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Abstract

Hypoxia is a common phenomenon in solid tumours and is considered a hallmark of cancer. Increasing evidence shows that hypoxia promotes local immune suppression. Type I IFN is involved in supporting cytotoxic T lymphocytes by stimulating the maturation of dendritic cells (DCs) and enhan...read more

Mentioned in this Paper

Antigens
Malignant Neoplasm of Breast
Malignant Neoplasms
Chromatin
Dendritic Cells
DNA
Down-Regulation
Gene Expression
Interferons
Neoplasms
8
2
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Hypoxia induces transcriptional and translational downregulation of the type I interferon (IFN) pathway in multiple cancer cell types

bioRxiv

Jul 25, 2019

Ana MiarAdrian L. Harris

DOI: 10.1101/715151

Abstract

Hypoxia is a common phenomenon in solid tumours and is considered a hallmark of cancer. Increasing evidence shows that hypoxia promotes local immune suppression. Type I IFN is involved in supporting cytotoxic T lymphocytes by stimulating the maturation of dendritic cells (DCs) and enhan...read more

Mentioned in this Paper

Antigens
Malignant Neoplasm of Breast
Malignant Neoplasms
Chromatin
Dendritic Cells
8
2

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