Hypoxia-Inducible Exosomes Facilitate Liver-Tropic Premetastatic Niche in Colorectal Cancer.

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Hao SunRui Chen

Abstract

Liver metastasis is a frequent occurrence in patients with colorectal cancer (CRC), with 15%-25% of CRC patients having liver metastases at the time of initial diagnosis. Specifically, some regional-stage patients with mild symptoms (stage 1 or 2) will also advance to liver metastases rapidly, even if the CRC lesion in situ is resected in time. Nevertheless, the precise mechanism of liver metastasis is still unclear. Fresh tumor tissues from patients with CRC, adjacent noncancerous tissues, and colorectal adenoma tissues were subjected to microarray analysis to identify differentially expressed microRNA. Exosomes from human serum and cell culture medium were separated, quantitated, and verified by transmission electronic microscopy and Zetasizer Nano. Luciferase reporter assay, real-time quantitative PCR, western blot, immunoprecipitation, chromatin and re-chromatin immunoprecipitation, migration and invasion assay, PDX mouse model, flow cytometry, immunohistochemistry, and immunofluorescence staining were employed to explore the regulation among CRC liver metastases, immunosuppression, and cell adhesion. In this study, we demonstrated that the hypoxic microenvironment in primary CRC lesions boosted exosome release, selectively...Continue Reading

References

Aug 3, 2002·Nature Reviews. Cancer·Ann F ChambersIan C MacDonald
Dec 30, 2006·Molecular and Cellular Biology·Ritu KulshreshthaMircea Ivan
Apr 30, 2010·The New England Journal of Medicine·Manuel Hidalgo
Oct 21, 2010·Cancer Prevention Research·Yoshikatsu KogaYasuhiro Matsumura
Jan 22, 2011·Seminars in Cancer Biology·Héctor PeinadoDavid Lyden
Aug 31, 2011·F1000 Biology Reports·Clotilde Théry
Mar 29, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shouyu WangJianwei Zhou
Nov 1, 2012·Cell Cycle·Ling FangBurton B Yang
Feb 15, 2013·Immunological Reviews·Hyunju Oh, Sankar Ghosh
Mar 19, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Aug 27, 2014·Cellular and Molecular Life Sciences : CMLS·Sarmad N Saleem, Asim B Abdel-Mageed
May 20, 2015·Nature Cell Biology·Bruno Costa-SilvaDavid Lyden
Sep 19, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ana Sebio, Heinz-Josef Lenz
Nov 3, 2015·Nature·Ayuko HoshinoDavid Lyden
Jan 26, 2016·Nature Reviews. Immunology·Adelheid Cerwenka, Lewis L Lanier
Apr 30, 2016·Annals of Clinical Biochemistry·Qinjun WangShaoqing Ju
Nov 16, 2016·Cancer Cell·Yang Liu, Xuetao Cao
Dec 14, 2016·Cancer Cell·Annette BeckerDavid Lyden
Mar 18, 2017·Nature Reviews. Cancer·Héctor PeinadoDavid Lyden

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.