Hypoxia-Inducible Factor-1α and CD271 inversely correlate with melanoma invasiveness

Experimental Dermatology
Alessandra MarconiCarlo Pincelli

Abstract

Melanoma is characterized, among other features, by microenvironmental factors and by an altered apoptotic machinery. Melanoma cell response to a hypoxic environment is transcriptionally regulated by the Hypoxia-Inducible Factor (HIF)-1α. p75 neurotrophin receptor (p75(NTR) ), also called CD271, mediates apoptosis in several cell systems. The purpose of this study was to analyze the expression of HIF-1α and CD271 in melanomas at different phases of progression, as evaluated by histology and reflectance confocal microscopy (RCM). By RCM, 41.67% tumors were characterized by the presence of a population of dendritic and pleomorphic cells (D+P), corresponding to in situ melanoma; 25% exhibited a predominantly round-cell (RN) proliferation with histologic features of superficial melanoma, and 33.33% showed the presence of cells aggregated in nests (DN), typical of invasive melanoma. HIF-1α was scarcely detected in D+P and in RN melanomas, while it was highly expressed in DN tumors. By contrast, CD271 positive cells were mostly detected in D+P population, and barely observed in the other subtypes. This work demonstrates that CD271 expression inversely correlates with hypoxia in melanoma, and that the two markers may be used in the fu...Continue Reading

References

Nov 14, 2007·Methods in Enzymology·Denise A ChanAmato J Giaccia
Feb 29, 2008·The Journal of Investigative Dermatology·Francesca TruzziCarlo Pincelli
Nov 8, 2011·Molecular Cell·Natacha Le MoanKaterina Akassoglou
Mar 12, 2013·The Journal of Investigative Dermatology·Daniel S WidmerMitchell P Levesque
Apr 9, 2013·The Journal of Clinical Investigation·Sara C HannaWilliam Y Kim
Apr 23, 2014·Experimental Dermatology·Giovanni PellacaniCaterina Longo

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Citations

Mar 23, 2017·Frontiers in Medicine·Carlo Pincelli
May 16, 2015·Experimental Dermatology·Daniel S WidmerMitchell P Levesque
May 10, 2021·Journal of Experimental & Clinical Cancer Research : CR·Simona D'AguannoAntonietta Moramarco

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