Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease

Pediatric Research
G L Semenza

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that mediates changes in gene expression in response to changes in cellular oxygen concentrations. HIF-1 is a heterodimer consisting of an oxygen-regulated HIF-1 alpha subunit and a constitutively expressed HIF-1 beta subunit. In mice, complete HIF-1 alpha deficiency results in embryonic lethality at midgestation because of cardiac and vascular malformations. Analyses of animal and cell culture models as well as human tissue have provided evidence that HIF-1 plays important roles in the pathophysiology of preeclampsia, intrauterine growth retardation, hypoxia-mediated pulmonary hypertension, and cancer. HIF-1 promotes neovascularization in response to myocardial or retinal ischemia by activating transcription of the gene encoding vascular endothelial growth factor. HIF-1 may also mediate the protective response to cerebral ischemia known as late-phase preconditioning.

References

Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·L P AielloL E Smith
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
Jan 20, 1995·The Journal of Biological Chemistry·G L Wang, G L Semenza
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·E A PierceL E Smith
Jul 26, 1996·The Journal of Biological Chemistry·B H JiangG L Semenza
Apr 25, 1997·The Journal of Biological Chemistry·C W PughP J Ratcliffe
May 15, 1997·Nature·Y HauptM Oren
May 15, 1997·Nature·M H KubbutatK H Vousden
Aug 8, 1997·The Journal of Biological Chemistry·A RolfsR H Wenger
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·A D EckhartJ E Faber
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·M SakanakaR Sasaki
Aug 13, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T HayashiY Itoyama
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·S I TazukeL C Giudice
Jan 13, 1999·Circulation·A RivardJ M Isner
Jan 14, 1999·Genes & Development·S BhattacharyaD M Livingston
Feb 13, 1999·The European Journal of Neuroscience·M OkadaS Kaneko
Aug 14, 1999·The Journal of Biological Chemistry·C N Lok, P Ponka
Feb 23, 2000·FEBS Letters·E MinetC Michiels
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·C H SutterG L Semenza
Apr 25, 2000·The Journal of Biological Chemistry·C K MukhopadhyayP L Fox
May 9, 2000·The Journal of Biological Chemistry·Y TakahashiT Miura
May 23, 2000·Critical Reviews in Biochemistry and Molecular Biology·G L Semenza
May 24, 2000·The Journal of Biological Chemistry·M E CockmanP H Maxwell

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Citations

Mar 13, 2012·Journal of Bioenergetics and Biomembranes·Céline PinheiroFátima Baltazar
Sep 15, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Xilin SunXiaoyuan Chen
Mar 5, 2013·Applied Biochemistry and Biotechnology·Mrinalini SinghAnju Bansal
Sep 24, 2010·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Gerald M Higa
May 24, 2011·Translational Stroke Research·Michelle Y ChengRobert M Sapolsky
Apr 13, 2005·Neuroscience Letters·Shannon Elise Goldsmith HamrickDonna Marie Ferriero
Mar 11, 2004·Experimental and Molecular Pathology·Khaled M MohamedDiana V Messadi
Sep 19, 2003·Hearing Research·Johann GrossT Kietzmann
Jan 23, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B G WoutersP Lambin
Jul 20, 2002·Respiratory Physiology & Neurobiology·Gregory B Waypa, Paul T Schumacker
Sep 19, 2003·Antioxidants & Redox Signaling·Nobuhito GodaRandall S Johnson
Sep 15, 2009·Glycobiology·Annika AsplundGöran Bondjers
Sep 1, 2007·American Journal of Respiratory and Critical Care Medicine·Argyris TzouvelekisVassilis Aidinis
Apr 1, 2006·American Journal of Respiratory Cell and Molecular Biology·Kyung Sun LeeYong Chul Lee
Nov 23, 2013·International Urology and Nephrology·Ljubinka Jankovic Velickovic, Vladisav Stefanovic
Mar 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Qing LiuThomas Kietzmann
Sep 17, 2009·Cellular and Molecular Life Sciences : CMLS·James D WebbChristopher W Pugh
Sep 22, 2007·International Journal of Radiation Biology·Chong-Jin FengHan-Yu Wang
Jan 26, 2016·Journal of Pharmaceutical and Biomedical Analysis·C BuissonA Molina
Jan 30, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Zsolt FábiánLan K Nguyen
Aug 21, 2004·The Journal of Physiology·Malgorzata MilkiewiczStuart Egginton
May 31, 2011·Gynecologic Oncology·Zhongliang JiangGhassan M Saed
Jan 5, 2011·Nitric Oxide : Biology and Chemistry·Nels Olson, Albert van der Vliet
Jan 1, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Stefanie KewitzMartin S Staege
Oct 30, 2009·The Journal of Allergy and Clinical Immunology·So Ri KimYong Chul Lee
Nov 17, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Wanfu WuWenqin Cai
Jun 23, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·José G Soñanez-OrganisGloria Yepiz-Plascencia
Apr 22, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Simon NagelAlastair M Buchan
Sep 30, 2005·The European Journal of Neuroscience·Eric W BrunskillCharles V Vorhees

❮ Previous
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