Hypoxia inducible factor-1α knockout does not impair acute thermal tolerance or heat hardening in zebrafish.

Biology Letters
William Joyce, Steve F Perry

Abstract

The rapid increase in critical thermal maximum (CTmax) in fish (or other animals) previously exposed to critically high temperature is termed 'heat hardening', which likely represents a key strategy to cope with increasingly extreme environments. The physiological mechanisms that determine acute thermal tolerance, and the underlying pathways facilitating heat hardening, remain debated. It has been posited, however, that exposure to high temperature is associated with tissue hypoxia and may be associated with the increased expression of hypoxia-inducible factor-1 (Hif-1). We studied acute thermal tolerance in zebrafish (Danio rerio) lacking functional Hif-1α paralogs (Hif-1aa and Hif-1ab double knockout; Hif-1α-/-), which are known to exhibit markedly reduced hypoxia tolerance. We hypothesized that Hif-1α-/- zebrafish would suffer reduced acute thermal tolerance relative to wild type and that the heat hardening ability would be lost. However, on the contrary, we observed that Hif-1α-/- and wild-type fish did not differ in CTmax, and both genotypes exhibited heat hardening of a similar degree when CTmax was re-tested 48 h later. Despite exhibiting impaired hypoxia tolerance, Hif-1α-/- zebrafish display unaltered thermal tolerance...Continue Reading

References

Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
Apr 6, 2000·Journal of Applied Physiology·G L Semenza
Nov 3, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·P W Hochachka, P L Lutz
Jan 10, 2002·The Journal of Biological Chemistry·Dorthe M KatschinskiRoland H Wenger
Apr 11, 2003·Physiological Genomics·Millet TreininMichal Horowitz
May 14, 2005·Science·Allison L PerryJohn D Reynolds
Jan 5, 2006·The Journal of Experimental Biology·Katja HeiseHans-O Pörtner
Jun 8, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Hans O PörtnerGeorge Somero
Nov 1, 2008·Science·Hans O Pörtner, Anthony P Farrell
Apr 7, 2009·Biological Reviews of the Cambridge Philosophical Society·Karin S KassahnM Julian Caley
Apr 29, 2011·The Journal of Experimental Biology·Sacha LeBlancSuzanne Currie
Jul 7, 2011·American Journal of Physiology. Endocrinology and Metabolism·Md Saydur Rahman, Peter Thomas
Jul 12, 2011·Physiological and Biochemical Zoology : PBZ·Jody M Beers, Bruce D Sidell
Aug 9, 2012·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Lucia VergauwenRonny Blust
Aug 18, 2012·The Journal of Experimental Biology·Dao H Ho, Warren W Burggren
Jul 12, 2013·The Journal of Experimental Biology·Timothy D ClarkFredrik Jutfelt
May 31, 2015·The Journal of Experimental Biology·Jeroen BrijsErik Sandblom
Apr 16, 2016·Physiological and Biochemical Zoology : PBZ·Devin P DevorElizabeth L Crockett
Jul 1, 2014·Temperature : Multidisciplinary Biomedical Journal·Brett R ElyChristopher T Minson
Nov 4, 2016·The Journal of Experimental Biology·Rasmus ErnAndrew J Esbaugh
Dec 3, 2016·Laboratory Animals·Tânia MartinsLuis M Antunes
May 20, 2017·Nature Communications·Claudia GerriDidier Y R Stainier
Aug 5, 2017·The Journal of Experimental Biology·Hans-O PörtnerFelix C Mark
Jan 13, 2018·The Journal of Experimental Biology·Fredrik JutfeltTimothy D Clark
May 10, 2018·Scientific Reports·Rachael MorganFredrik Jutfelt
Jan 6, 2019·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Long-Yan ZhouXiu-Ming Li
May 6, 2019·Science China. Life Sciences·Phei Er Saw, Er-Wei Song
May 10, 2019·Physiological and Biochemical Zoology : PBZ·Kelly D LevesqueNicholas J Bernier
Jun 15, 2019·Proceedings of the National Academy of Sciences of the United States of America·Romana BohuslavovaGabriela Pavlinkova
May 27, 2020·Proceedings. Biological Sciences·Milica MandicSteve F Perry

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Citations

Jul 22, 2021·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·William Joyce, Steve F Perry
Sep 18, 2021·The Journal of Experimental Biology·Milica MandicSteve F Perry

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