PMID: 7538678May 9, 1995Paper

Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells

Proceedings of the National Academy of Sciences of the United States of America
K KuwabaraJ Joseph-Silverstein

Abstract

Wound repair and tumor vascularization depend upon blood vessel growth into hypoxic tissue. Although hypoxia slows endothelial cell (EC) proliferation and suppresses EC basic fibroblast growth factor (bFGF) expression, we report that macrophages (MPs) exposed to PO2 approximately 12-14 torr (1 torr = 133.3 Pa) synthesize and release in a time-dependent manner platelet-derived growth factor (PDGF) and acidic/basic FGFs (a/bFGFs), which stimulate the growth of hypoxic ECs. Chromatography of hypoxic MP-conditioned medium on immobilized heparin with an ascending NaCl gradient resolved three peaks of mitogenic activity: activity of the first peak was neutralized by antibody to PDGF; activity of the second peak was neutralized by antibody to aFGF; and activity of the third peak was neutralized by antibody to bFGF. Metabolically labeled lysates and supernatants from MPs exposed to hypoxia showed increased synthesis and release of immunoprecipitable PDGF and a/bFGF in the absence of changes in cell viability. Possible involvement of a heme-containing oxygen sensor in MP elaboration of growth factors was suggested by the induction of bFGF and PDGF by normoxic MPs exposed to nickel or cobalt, although metabolic inhibitors such as sodium ...Continue Reading

References

Sep 1, 1992·The Journal of Clinical Investigation·S KogaD K Burns
Jun 1, 1990·The Journal of Clinical Investigation·V LindnerM A Reidy
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P Delli Bovi, C Basilico
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G L Wang, G L Semenza
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·P H MaxwellP J Ratcliffe

❮ Previous
Next ❯

Citations

Nov 6, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kristine GlundeZaver M Bhujwalla
Jan 1, 1995·Molecular Biology Reports·R P Dirks, H P Bloemers
Mar 11, 2008·Angiogenesis·Guo-Hua Fong
Dec 4, 2003·Mutation Research·Gabriel Keith Harris, Xianglin Shi
Dec 28, 1999·Brain Research. Developmental Brain Research·Y ZhangJ Stone
Jan 8, 1999·International Journal of Cardiology·A KawamotoK Dohi
Feb 25, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·G CoxK J O'Byrne
Sep 8, 1998·International Journal of Immunopharmacology·M IchinoseY Oomura
Mar 18, 2000·Experimental Hematology·D L HevehanW M Miller
Jan 23, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B G WoutersP Lambin
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P B VermeulenL Y Dirix
Apr 15, 2003·Trends in Cardiovascular Medicine·Rohit Khurana, Michael Simons
Nov 1, 1997·Trends in Cardiovascular Medicine·Y Dor, E Keshet
Jan 1, 1998·Trends in Cardiovascular Medicine·J F Schmedtje, Y S Ji
Nov 25, 2003·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Andreas H ZischJeffrey A Hubbell
Mar 5, 1999·Breast Cancer Research and Treatment·M ToiT Tominaga
Nov 13, 2008·Cytotechnology·J Mattern, M Volm
Feb 1, 1997·Nature Medicine·J A Ware, M Simons
Feb 27, 2003·European Journal of Biochemistry·Rebecca L Bilton, Grant W Booker
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·M GassmannH Acker
Mar 19, 2009·Tissue Engineering. Part a·Craig K Griffith, Steven C George
Jan 15, 2000·Annals of Surgery·Z A HaroonM W Dewhirst
Oct 30, 2008·Current Opinion in Lipidology·Jannick Pétremand, Christian Widmann
Aug 26, 1998·Molecular Pathology : MP·J A RoydsC E Lewis
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·Y Z GuC A Bradfield
Jan 13, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jeon-Ok MoonBryan L Copple
Oct 11, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Martin Rodriguez-PorcelLilach O Lerman
May 12, 2012·Mediators of Inflammation·Konstantinos KaratoliosSabine Pankuweit
Sep 10, 2009·American Journal of Respiratory Cell and Molecular Biology·Mark F CestaJames C Bonner
Apr 1, 1997·The Journal of Clinical Investigation·C A LawsonD J Pinsky
Nov 21, 2007·Journal of Cardiothoracic Surgery·Hilal Al Sabti
May 4, 2005·Environmental Health Perspectives·Konstantin Salnikow, Kazimierz S Kasprzak
Aug 6, 2004·International Journal of Hematology·Yuichi OikeToshio Suda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.