PMID: 2119852Jul 16, 1990Paper

Hypoxia prevents seizures and neuronal damages of the hippocampus induced by kainic acid in rats

Brain Research
S AmanoM Shimada

Abstract

The effects of hypoxia on the epileptic seizures and neuronal damages induced by kainic acid were studied in rats using hypoxic chamber equipment. Rats treated with kainic acid and placed in atmospheric pressure showed typical limbic seizures and regressive neuronal changes in CA3 and CA4 of the hippocampus, while those kept in a hypoxic chamber with 8.5% O2 and 91.5% N2 showed moderate hypoxia and a slight decline of mean arterial blood pressure. In these hypoxic rats, seizures were completely prevented and there was remarkably less regressive neuronal injury of the hippocampus. Thus hypoxia has a rather ameliorative effect on the occurrence of seizures and excitotoxic neuronal injuries induced by kainic acid. The contribution of oxygen radicals and endogenous adenosine to preventing excitotoxic neuronal damages by kainic acid was discussed.

References

Nov 1, 1979·Canadian Journal of Physiology and Pharmacology·J W PhillisJ R Kirkpatrick
May 1, 1975·Journal of Neurochemistry·T E DuffyF Plum
Oct 26, 1979·Brain Research·J W OlneyT de Gubareff
Jul 1, 1979·Acta Physiologica Scandinavica·B K Siesjö, A Abdul-Rahman
Jun 30, 1978·Brain Research·S M WuertheleK E Moore
Dec 1, 1978·Brain : a Journal of Neurology·G BlennowB K Siesjö
Dec 1, 1988·Journal of Neurochemistry·D E Pellegrini-GiampietroF Moroni
Apr 1, 1986·British Journal of Pharmacology·B Ault, C M Wang
May 1, 1988·Naunyn-Schmiedeberg's Archives of Pharmacology·H L Haas, R W Greene
Sep 13, 1974·Brain Research·J W OlneyO L Ho
Jun 15, 1980·Biochemical Pharmacology·B B Fredholm, P Hedqvist
Jan 1, 1981·Nature·A C FosterC W Cotman
Aug 1, 1983·Pharmacology, Biochemistry, and Behavior·T E AlbertsonL G Stark
Jun 1, 1984·Experimental Neurology·M Dragunow, G V Goddard
Jun 23, 1980·Brain Research·R W HortonJ R McWilliam

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Citations

Mar 29, 1996·Brain Research. Developmental Brain Research·T MorimotoK Kida
Jan 1, 1994·Progress in Neurobiology·G Sperk
May 14, 1993·Neuroscience Letters·P Casaccia-BonnefilP J Bergold
Feb 7, 1997·Neuroscience Letters·M SasahiraD A Greenberg
Nov 25, 1997·Annals of the New York Academy of Sciences·Z Binienda
Aug 7, 2003·Journal of Neuropathology and Experimental Neurology·Linda K FriedmanHongguang Liu
Aug 9, 2020·Journal of Clinical Medicine·Candice FontaineStephane Legriel
Oct 18, 2020·Clinical Physiology and Functional Imaging·Priyadarshini MishraManish Goyal
Jan 13, 2021·International Journal of Molecular Sciences·Johannes BurtscherLuca Zangrandi
Jan 7, 1999·Cellular and Molecular Neurobiology·F FacchinettiT M Dawson

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