Hypoxia recruits intrapulmonary arteriovenous pathways in intact rats but not isolated rat lungs

Journal of Applied Physiology
Melissa L BatesMarlowe W Eldridge

Abstract

Intrapulmonary arteriovenous anastomoses (IPAVS) directly connect the arterial and venous circulations in the lung, bypassing the capillary network. Here, we used solid, latex microspheres and isolated rat lung and intact, spontaneously breathing rat models to test the hypothesis that IPAVS are recruited by alveolar hypoxia. We found that hypoxia recruits IPAVS in the intact rat, but not the isolated lung. IPAVS are at least 70 μm in the rat and, interestingly, appear to be recruited when the mixed venous Po(2) falls below 22 mmHg. These data provide evidence that large-diameter, direct arteriovenous connections exist in the lung and are recruitable by hypoxia in the intact animal.

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Citations

Oct 29, 2013·Annals of the American Thoracic Society·Andrew T LoveringBernard Thébaud
Feb 5, 2013·The Journal of Physiology·Melissa L BatesEmily T Farrell
Jan 8, 2015·The Journal of Physiology·Andrew T LoveringJonathan E Elliott
Jan 30, 2015·Medicine and Science in Sports and Exercise·Otto F BarakZeljko Dujic
May 8, 2013·Respiratory Physiology & Neurobiology·Jonathan E ElliottAndrew T Lovering
Nov 9, 2016·Physiological Reports·Robert L ConhaimKal E Watson
Mar 31, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Melissa L BatesLuke J Lamers
May 9, 2014·Journal of Biomechanical Engineering·Sarah Duenwald-KuehlRay Vanderby
Nov 15, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kayla L MosesMelissa L Bates
Aug 4, 2012·Journal of Applied Physiology·Steven S LaurieAndrew T Lovering
Mar 15, 2014·Journal of Applied Physiology·H Cameron NorrisAndrew T Lovering

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