PMID: 11334203May 4, 2001Paper

Hypoxia, reoxygenation and the role of systemic leukodepletion in pediatric heart surgery

Perfusion
B S Allen, M N Ilbawi

Abstract

As cardiopulmonary bypass (CPB) in infants and neonates is becoming more frequent, the technical performance of these operations for congenital heart disease has made significant progress. However, little research has been carried out into the conduct of CBP in producing myocardial and pulmonary dysfunction. Postoperative organ dysfunction is a problem, particularly for cyanotic infants. This paper examines the experimental and clinical experience of injury brought about by abrupt reoxygenation of the hypoxic, or cyanotic, heart. The modalities of gradual reoxygenation and leukodepletion in limiting this injury are examined, leading to the conclusion that injury can be reduced and possibly ameliorated by changes in intraoperative management during CBP in children with cyanotic disease.

References

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Citations

Dec 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Bradley S AllenZhongtou Tan
Jul 31, 2004·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Bradley S Allen
Feb 21, 2006·Annales Françaises D'anesthèsie Et De Rèanimation·C BaufretonF Pinaud
Mar 27, 2003·The Journal of Thoracic and Cardiovascular Surgery·Bradley S AllenLouis J Ignarro
Sep 22, 2001·Perfusion·S J Morris
Jan 25, 2003·Critical Care Medicine·Bernd FriedrichLudwig Gortner

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