Hypoxia-specific targets in cancer therapy: role of splice variants.

BMC Medicine
Dirk Vordermark

Abstract

Tumour hypoxia is a well known adverse prognostic factor in the treatment of solid tumours. Hypoxia-inducible factor 1alpha (HIF-1alpha), a transcription factor subunit regulating a large number of hypoxia-responsive genes, is considered an attractive target for novel treatment approaches, due to a frequently reported association between HIF-1alpha overexpression and poor outcome in clinical series. This month in BMC Medicine, Dales et al. report on splice variants of HIF-1alpha in fresh frozen tissue samples of early human breast cancer, finding an association of mRNA levels of the variant HIF-1alphaTAG with adverse clinical factors (lymph node status, hormone receptor status) and poor metastasis-free survival. This preliminary study addresses the possibility that specific targeting of individual isoforms resulting from alternative splicing may play a role in HIF-1-directed treatment approaches.

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Citations

Jan 15, 2014·PloS One·Bruna Victorasso Jardim-PerassiDebora Aparecida Pires de Campos Zuccari
Jun 23, 2012·World Journal of Clinical Oncology·Feray KockarHarun M Said
Sep 6, 2011·Virchows Archiv : an International Journal of Pathology·Juliana Silva ZanettiAlfredo Ribeiro-Silva
Dec 11, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·C OstheimerD Vordermark
Aug 1, 2013·Acta histochemica·Larissa Bazela MaschioDebora Aparecida Pires de Campos Zuccari
Jun 17, 2020·Journal of Experimental & Clinical Cancer Research : CR·Antonietta Rosella FarinaAndrew Reay Mackay

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Methods Mentioned

BETA
PCR

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