Hypoxia-specific therapeutic agents delivery nanotheranostics: A sequential strategy for ultrasound mediated on-demand tritherapies and imaging of cancer

Journal of Controlled Release : Official Journal of the Controlled Release Society
Qianhua FengZhenzhong Zhang

Abstract

The hypoxic microenvironment induced by sonodynamic therapy (SDT) via sonochemical oxygen consumption usually triggered tumor resistance to SDT, impeding therapeutic efficacy. In this sense, it was highly desired to tackle the hypoxia-related negative issues. Here we provide the therapeutic agents delivery system, TPZ/HMTNPs-SNO, which was constructed by loading tirapazamine (TPZ) into hollow mesoporous titanium dioxide nanoparticles (HMTNPs) with modification of S-nitrosothiol (R-SNO). Upon encountering ultrasound waves, the HMTNPs as sonosensitizers would generate reactive oxygen species (ROS) for SDT. In a sequential manner, the followed SDT-induced hypoxia further activated the "hypoxic cytotoxin", TPZ, for hypoxia-specific killing effect. Meanwhile, the generated ROS could sensitize -SNO groups for on-demand nitric oxide (NO) release in an "anticancer therapeutic window", resulting in the NO sensitized SDT effect. This study confirmed that the TPZ/HMTNPs-SNO with multi-mechanisms exploited the merits of synergistic combination of the three therapeutic modes, consequently potentiating the anticancer efficacy of SDT. Moreover, the echogenic property of NO made the nanoplatform as an ultrasound contrast agent to enhance ultra...Continue Reading

Citations

Aug 4, 2018·Advanced Healthcare Materials·Jabran SaleemChunying Chen
Jul 10, 2019·Journal of Drug Targeting·Yingjie ZhangXiaojian Zhang
Dec 18, 2019·Proceedings of the National Academy of Sciences of the United States of America·Maonan WangXuemei Wang
Aug 30, 2018·Biomaterials Research·Saji UthamanIn-Kyu Park
Sep 7, 2019·Advanced Materials·Qingling SongYun Zhang
Apr 28, 2020·Chemical Society Reviews·Subin SonJong Seung Kim
Jun 6, 2019·Frontiers in Pharmacology·Kazuhisa TakemaeYoshihiro Muragaki
Sep 5, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xueke SunHongwei Song
Oct 24, 2020·Nanoscale·Aravindkumar SundaramHan Zhang
Oct 29, 2020·Chemical Society Reviews·Jiajie ChenJianlin Shi
Feb 7, 2021·Colloids and Surfaces. B, Biointerfaces·Keyi LuoShige Wang
Apr 27, 2021·Journal of Drug Targeting·Yingjie ZhangXiaojian Zhang
Apr 27, 2021·Nano Today·Jinping WangHongjun Wang
Apr 21, 2018·Biomacromolecules·Santhosh Kalash RajendrakumarIn-Kyu Park
Nov 18, 2021·Advanced Healthcare Materials·Shuting LuZhongqian Hu

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