PMID: 2495840Mar 20, 1989Paper

Hypoxic and hypercapnic responses of [Ca2+]o and [K+]o in the cat carotid body in vitro

Brain Research
M A Delpiano, H Acker

Abstract

Measurements of extracellular Ca2+ and K+ activities [( Ca2+]o, [K+]o) in the superfused cat carotid body in vitro with triple-barrelled ion-selective electrodes have shown that hypoxia induced a decrease in [Ca2+]o of 0.035 +/- 0.17 mM (mean +/- S.D.; n = 17) and a biphasic change in [K+]o which consisted of an increase of 2.3 +/- 1.8 mM followed by an undershoot of -0.52 +/- 0.34 mM (mean +/- S.D.; n = 17). Hypercapnia induced a monophasic upward deflection increase of both [Ca2+]o and [K+]o of about 0.037 +/- 0.013 mM and 0.33 +/- 0.15 mM, respectively (n = 17). During hypoxia, lowering [Ca2+] in the medium to 0.1 mM resulted in a reversed [Ca2+]o response, attenuated [K+]o increase and absence of chemosensory nerve discharges. TTX generally did not affect the hypoxic and hypercapnic induced ionic changes, although the [K+]o undershoot was reduced by 30%. Co2+ competitively blocked the changes in [Ca2+]o and the increase in the sensory nerve discharge elicited by hypoxia and, not competitively, the changes of [K+]o. The ionic changes to hypercapnia were less affected by Co2+. Ouabain inhibited the [K+]o undershoot induced by hypoxia, as did the removal of Na+ from medium. It is concluded that changes in extracellular free Ca...Continue Reading

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Citations

Nov 1, 1992·Journal of the Autonomic Nervous System·H AckerG Holtermann
Jun 19, 2001·The International Journal of Biochemistry & Cell Biology·S LahiriD G Buerk
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·S LahiriH Acker
Jul 1, 1991·Journal of Neurochemistry·M A Delpiano, H Acker
Apr 26, 2005·Respiratory Physiology & Neurobiology·Toru TakahashiKenjiro Kikuchi
Feb 10, 1995·The Journal of Biological Chemistry·E GoldwasserA Gardner
Dec 15, 1995·Annals of the New York Academy of Sciences·J L Cummings
Jan 23, 2020·American Journal of Physiology. Cell Physiology·André BernardiniHelmut Acker

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