Hypoxic and hypercapnic ventilatory responses during isoflurane sedation and anaesthesia in women

Acta Anaesthesiologica Scandinavica
A Sollevi, S G Lindahl


This study primarily examined the effect of three endtidal isoflurane concentrations (0.2, 1.0 and 1.4%) on the isocapnic hypoxic ventilatory response (HVR), as well as the hypercapnic ventilatory response (HCVR), in 18 women (ASA I) who were all in the follicular phase of their menstrual cycle. Capnography was used, together with pulseoximetry to indicate desired levels of hypoxia (SpO2 75-80%). This hypoxic challenge resulted, after 3-4 min, in a stable ventilation, and ventilation measurements were then taken during a 90 s period. The HCVR provocation (inhalation of 4.5% CO2 in air) and measurements were conducted using a similar time frame as for HVR. Isoflurane 0.2% did not affect any ventilatory parameter. Isoflurane 1.0 and 1.4% dose-dependently increased endtidal CO2 and respiratory rate, while tidal volumes decreased. Minute ventilation was not reduced. HVR, as well as HCVR, were both uninfluenced by isoflurane 0.2%. HVR was reduced by 60-70% at isoflurane 1.4% (P < 0.01), and was parallelled by a similar depression of HCVR (P < 0.01). The HVR during anaesthesia was accomplished by a respiratory rate response, while the increase in tidal volume, seen in the awake state, was abolished. The HCVR during anaesthesia was, o...Continue Reading


Sep 1, 1979·Canadian Anaesthetists' Society Journal·R L KnillJ L Clement
Nov 1, 1978·Canadian Anaesthetists' Society Journal·A W Gelb, R L Knill
Oct 1, 1977·British Journal of Anaesthesia·C A HirshmanJ V Weil
Jan 1, 1975·Journal of Applied Physiology·A S Rebuck, W E Woodley
Nov 1, 1990·British Journal of Anaesthesia·S O Koh, J W Severinghaus
Nov 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J Duffin
Dec 1, 1985·British Journal of Anaesthesia·I MuratC Saint-Maurice
Aug 1, 1973·Journal of Applied Physiology·W J Reynolds, H T Milhorn
Nov 1, 1983·Canadian Anaesthetists' Society Journal·R L KnillJ L Clement
Jun 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R B SchoeneA P Peterson
Jan 1, 1995·Acta Anaesthesiologica Scandinavica·D SjögrenS G Lindahl
Feb 1, 1994·Acta Anaesthesiologica Scandinavica·D SjögrenS G Lindahl
May 1, 1994·British Journal of Anaesthesia·N W Goodman
May 1, 1994·British Journal of Anaesthesia·B NagyovaPeter A Robbins
Nov 1, 1961·Journal of Neurophysiology·T F HORNBEINA ROOS


Oct 29, 2004·Current Opinion in Pulmonary Medicine·Sanjay S Jain, Rajiv Dhand
Sep 20, 2012·Current Opinion in Pulmonary Medicine·Dennis Auckley, Norman Bolden
Feb 12, 1998·Anesthesia and Analgesia·D SjögrenA Sollevi
Jan 1, 2008·General Hospital Psychiatry·Jean K FleischmanJoseph P Merlino
Jun 29, 2014·Sleep & Breathing = Schlaf & Atmung·Dennis AuckleyJ Daryl Thornton
Jul 20, 2001·British Journal of Anaesthesia·D Pogson, S Johnston
Sep 3, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Frédéric S Dumont, Richard Kinkead

Related Concepts

Insufflation Anesthesia
Carbon Dioxide
Conscious Sedation
Anesthetic Gases

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.