Hypoxic and hypercapnic ventilatory responses during isoflurane sedation and anaesthesia in women

Acta Anaesthesiologica Scandinavica
A Sollevi, S G Lindahl

Abstract

This study primarily examined the effect of three endtidal isoflurane concentrations (0.2, 1.0 and 1.4%) on the isocapnic hypoxic ventilatory response (HVR), as well as the hypercapnic ventilatory response (HCVR), in 18 women (ASA I) who were all in the follicular phase of their menstrual cycle. Capnography was used, together with pulseoximetry to indicate desired levels of hypoxia (SpO2 75-80%). This hypoxic challenge resulted, after 3-4 min, in a stable ventilation, and ventilation measurements were then taken during a 90 s period. The HCVR provocation (inhalation of 4.5% CO2 in air) and measurements were conducted using a similar time frame as for HVR. Isoflurane 0.2% did not affect any ventilatory parameter. Isoflurane 1.0 and 1.4% dose-dependently increased endtidal CO2 and respiratory rate, while tidal volumes decreased. Minute ventilation was not reduced. HVR, as well as HCVR, were both uninfluenced by isoflurane 0.2%. HVR was reduced by 60-70% at isoflurane 1.4% (P < 0.01), and was parallelled by a similar depression of HCVR (P < 0.01). The HVR during anaesthesia was accomplished by a respiratory rate response, while the increase in tidal volume, seen in the awake state, was abolished. The HCVR during anaesthesia was, o...Continue Reading

References

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Citations

Oct 29, 2004·Current Opinion in Pulmonary Medicine·Sanjay S Jain, Rajiv Dhand
Sep 20, 2012·Current Opinion in Pulmonary Medicine·Dennis Auckley, Norman Bolden
Feb 12, 1998·Anesthesia and Analgesia·D SjögrenA Sollevi
Jan 1, 2008·General Hospital Psychiatry·Jean K FleischmanJoseph P Merlino
Jun 29, 2014·Sleep & Breathing = Schlaf & Atmung·Dennis AuckleyJ Daryl Thornton
Jul 20, 2001·British Journal of Anaesthesia·D Pogson, S Johnston
Sep 3, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Frédéric S Dumont, Richard Kinkead

Related Concepts

Insufflation Anesthesia
Anoxemia
Carbon Dioxide
Hypercapnia
Isoflurane
Dioxygen
Respiration
Conscious Sedation
Anesthetic Gases

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