Hypoxic depression of melatonin secretion after simulated long duration flights in man

Journal of Pineal Research
O CosteYvan Touitou

Abstract

Fatigue is often reported after long duration flights. Mild hypobaric hypoxia caused by pressurization may be involved in this effect through disruption of circadian rhythms, independent of the number of time zones crossed. In this controlled crossover study we assessed the effects of two levels of hypoxia equivalent to 8000 and 12,000 ft on the rhythm of plasma melatonin concentrations, a marker of circadian rhythmicity. Sixteen healthy young male volunteers (23-39 years) were exposed in a hypobaric chamber for 8 hr (08:00-16:00 hours) to 8000 ft, followed 4 wk later by 12,000 ft. Plasma melatonin was assayed over two 24-hr cycles (control and hypoxic exposure) every 2 hr in all subjects. We found a significant decrease in the nocturnal melatonin peak after hypoxic exposure at both altitudes, and we found that this effect was age dependent for the 12,000-ft exposure: the decrease was only seen in the younger subjects (23-28 years). Analysis of heart rate variability allowed us to demonstrate that the older and less trained subjects (29-39 yr) in our study exhibited a far greater increase in sympathetic tone than the younger subjects during the 12,000-ft exposure. These results show that hypoxic depression of melatonin secretio...Continue Reading

Citations

Feb 25, 2009·Travel Medicine and Infectious Disease·Olivier Coste, Didier Lagarde
Mar 21, 2007·Respiratory Physiology & Neurobiology·Jacopo P Mortola
Nov 1, 2006·Physiology & Behavior·Nigel T CableWarren A Gregson
Jan 31, 2006·Journal of Pineal Research·Yung-Wui TjongMan-Lung Fung
Aug 27, 2010·Journal of Fish Biology·S DufourC Pasqualini
Apr 23, 2014·Scandinavian Journal of Medicine & Science in Sports·P FowlerJ Vaile
Nov 13, 2014·European Journal of Applied Physiology·Peter M FowlerJoanna Vaile
Aug 4, 2016·Chronobiology International·Yvan TouitouAlain Reinberg
Mar 17, 2007·Chronobiology International·Olivier CosteYvan Touitou
Jul 17, 2018·Frontiers in Physiology·Marcelo TapiaClaus Behn
Apr 3, 2020·International Journal of Molecular Sciences·Claus Behn, Nicole De Gregorio
Sep 1, 2018·Physiology & Behavior·Valdir de Aquino LemosMarco Tulio De Mello

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