PMID: 3766903Jan 1, 1986Paper

Hypoxic-ischemic brain damage and cerebral blood flow changes in young rabbits

Brain & Development
S TakashimaK Takeshita

Abstract

Hypoxic-ischemic cerebral damage was demonstrated in the cerebral cortex of 2-week-old rabbits at 3 to 5 days after bilateral carotid artery ligation and reperfusion during hypoxemia. Carotid ligation and reperfusion had little effect on cortical blood flow during normoxemia, but the former suppressed a blood flow increase to hypoxemia and the latter suppressed a blood flow decrease to hyperoxemia. These results suggest a relative ischemia or vascular dysfunction which may play a part in the pathogenesis of the hypoxic-ischemic cortical necrosis.

References

Jan 1, 1973·Acta Physiologica Scandinavica·B Eklöf, B K Siesjö
Sep 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T MatsuyamaH Abe
Dec 1, 1984·Pediatric Research·J BelikM Delivoria-Papadopoulos
May 1, 1982·Annals of Neurology·W A PulsinelliF Plum
Feb 1, 1981·Annals of Neurology·J E RiceJ B Brierley

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