Hypoxic-Ischemic Encephalopathy Evaluated by Brain Autopsy and Neuroprognostication After Cardiac Arrest.

JAMA Neurology
Christian EndischChristoph Leithner

Abstract

Neuroprognostication studies are potentially susceptible to a self-fulfilling prophecy as investigated prognostic parameters may affect withdrawal of life-sustaining therapy. To compare the results of prognostic parameters after cardiac arrest (CA) with the histopathologically determined severity of hypoxic-ischemic encephalopathy (HIE) obtained from autopsy results. In a retrospective, 3-center cohort study of all patients who died following cardiac arrest during their intensive care unit stay and underwent autopsy between 2003 and 2015, postmortem brain histopathologic findings were compared with post-CA brain computed tomographic imaging, electroencephalographic (EEG) findings, somatosensory-evoked potentials, and serum neuron-specific enolase levels obtained during the intensive care unit stay. Data analysis was conducted from 2015 to 2020. The severity of HIE was evaluated according to the selective eosinophilic neuronal death (SEND) classification and patients were dichotomized into categories of histopathologically severe and no/mild HIE. Of 187 included patients, 117 were men (63%) and median age was 65 (interquartile range, 58-74) years. Severe HIE was found in 114 patients (61%) and no/mild HIE was identified in 73 pa...Continue Reading

References

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Citations

Apr 14, 2021·Resuscitation·Thijs M van SoestJanneke Horn
Mar 27, 2021·Current Opinion in Critical Care·Aurora Magliocca, Michael Fries
May 4, 2021·Minerva anestesiologica·Lorenzo Peluso, Nicolas Gaspard
Jul 14, 2021·Journal of Medical Ethics·Mayli MertensMarianne Boenink
Sep 25, 2021·Scientific Data·Martin G FraschReinhard Bauer

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