Hypoxic pulmonary vasoconstriction in cardiothoracic surgery: basic mechanisms to potential therapies

The Annals of Thoracic Surgery
Ben M TsaiDaniel R Meldrum

Abstract

Hypoxic pulmonary vasoconstriction is postulated to be an adaptive mechanism to match lung perfusion with ventilation; however, the consequences of the maladaptive effects of pulmonary vasoconstriction represent formidable therapeutic challenges. Understanding the basic mechanisms of hypoxic pulmonary vasoconstriction will enhance the assimilation of translational research into clinical practice. The purposes of this review are to (1) define basic mechanisms of pulmonary vasoconstriction and vasorelaxation; (2) delineate the biphasic contractile response to hypoxia; (3) critically examine data that support the mediator hypothesis versus the ion channel hypothesis; and (4) explore potential mechanistic-based therapies for hypoxic pulmonary vasoconstriction.

References

Sep 1, 1979·Intensive Care Medicine·F JardinA Margairaz
Jan 1, 1991·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·R A HopkinsJ Stark
Sep 1, 1991·The Journal of Clinical Investigation·S KourembanasD V Faller
Jun 29, 1990·Biochemical and Biophysical Research Communications·H RakugiN Suzuki
Jan 1, 1989·The Tohoku Journal of Experimental Medicine·M OheT Takishima
Nov 15, 1989·Biochemical and Biophysical Research Communications·S L ArcherE K Weir
Aug 1, 1966·Circulation Research·M Kato, N C Staub
Dec 1, 1983·Journal of the American College of Cardiology·J D WaldmanS J Pappelbaum
Jan 1, 1993·Journal of Cardiovascular Pharmacology·J WongJ R Fineman
Jan 15, 1995·The Journal of Physiology·Y WangF Coceani
Jan 1, 1995·Annual Review of Physiology·J R FinemanM A Heymann
Sep 22, 1994·European Journal of Pharmacology·J P DumasJ F Giudicelli
Jan 30, 1993·Lancet·I AdatiaD L Wessel
Dec 1, 1993·The American Review of Respiratory Disease·D LanglebenD J Stewart
Feb 11, 1993·The New England Journal of Medicine·R RossaintW M Zapol
Jul 15, 1993·The New England Journal of Medicine·M MonchiA T Dinh-Xuan
Feb 1, 1996·The New England Journal of Medicine·R J BarstUNKNOWN Primary Pulmonary Hypertension Study Group
Sep 1, 1995·Experimental Physiology·J P Ward, T P Robertson
Mar 1, 1996·American Journal of Respiratory and Critical Care Medicine·D WalmrathW Seeger
May 1, 1996·The Annals of Thoracic Surgery·M KadletzA S Wechsler
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·R ZiescheL H Block
Nov 1, 1996·American Journal of Respiratory Cell and Molecular Biology·C MarshallB E Marshall
Mar 1, 1997·The Journal of Trauma·B C SheridanD A Fullerton
Sep 26, 1997·Shock·B C SheridanD A Fullerton
Sep 2, 1998·The Annals of Thoracic Surgery·D R MeldrumA H Harken
Oct 17, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Albertini, M G Clement
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·B R JacobsD J Smith

❮ Previous
Next ❯

Citations

Sep 9, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Avihu Z Gazit
Dec 30, 2014·Archives of Toxicology·Carmen GonzalezSyed F Ali
Jan 16, 2007·Chest·Omar A MinaiAlejandro C Arroliga
Dec 24, 2015·Pulmonary Circulation·Seon-Jin LeeYang Jin
Feb 6, 2008·The Nursing Clinics of North America·Susan K Frazier
Sep 18, 2007·The Journal of Surgical Research·Ketan M PatelDaniel R Meldrum
Jun 19, 2007·The Journal of Surgical Research·Ben M TsaiDaniel R Meldrum
Feb 10, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Mohammed M MinhajAndrew Maslow
Feb 21, 2006·The Annals of Thoracic Surgery·Sophie JaillardLaurent Storme
May 16, 2006·Journal of Molecular and Cellular Cardiology·Eric D MorrellDaniel R Meldrum
May 25, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ben M TsaiDaniel R Meldrum
Aug 24, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ben M TsaiDaniel R Meldrum
Jun 23, 2006·Anesthesia and Analgesia·Andrew D MaslowArun K Singh
Jun 28, 2007·American Journal of Physiology. Endocrinology and Metabolism·Tim LahmDaniel R Meldrum
Jun 17, 2011·Anaesthesia and Intensive Care·R RajasekaramR Bellomo
Nov 3, 2017·Physiological Genomics·Hannah C SaternosWissam A AbouAlaiwi
Dec 8, 2020·Pulmonary Circulation·Veronica FrancoRaymond L Benza

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Related Papers

American Journal of Physiology. Lung Cellular and Molecular Physiology
Ben M TsaiDaniel R Meldrum
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Ben M TsaiDaniel R Meldrum
European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
R A HopkinsJ Stark
© 2022 Meta ULC. All rights reserved