PMID: 698869Sep 1, 1978Paper

Hypoxic ventilatory responses during thiopentone sedation and anaesthesia in man

Canadian Anaesthetists' Society Journal
R L KnillP Manninen

Abstract

We have assessed the impact of thiopentone on the hypoxic ventilatory reflex, and on the responses to carbon dioxide and doxapram. Thiopentone sedation did not detectably alter any of these aspects of ventilatory control. Thiopentone anaesthesia reduced ventilation and the ventilatory responses to hypoxia, carbon dioxide and doxapram, all approximately in paralle. We conclude that, in contrast to halothane, thiopentone does not selectively reduce the ventilatory response to hypoxia. During light thiopentone anaesthesia, a reasonably brisk hypoxic response is present.

References

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Citations

Feb 1, 1983·Pflügers Archiv : European journal of physiology·F HayashiY Honda
Sep 1, 1979·Canadian Anaesthetists' Society Journal·R L KnillJ L Clement
Nov 1, 1980·Canadian Anaesthetists' Society Journal·D C ChungJ Strupat
Nov 1, 1978·Canadian Anaesthetists' Society Journal·A W Gelb, R L Knill
Mar 1, 1982·Canadian Anaesthetists' Society Journal·R L Knill, J L Clement
Jan 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A M LynnE B Furman
Jul 1, 1986·Respiration Physiology·R F Fregosi, J A Dempsey
Jan 10, 2014·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Alison B Froese
Sep 1, 1984·American Journal of Medical Genetics·C M McCueW E Nance
Jan 1, 1990·Scandinavian Journal of Gastroenterology. Supplement·P M Lauven

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