Hysteresis in atrial refractoriness in the conscious dog: influence of stimulation parameters and control by the autonomic nervous system

Journal of Cardiovascular Pharmacology
M BoucherP Lorente

Abstract

This work (a) provides evidence for hysteresis in the atrial effective refractory period (AERP) in the conscious dog; (b) studies the main stimulation parameters that may affect this phenomenon; and (c) evaluates the influence of the autonomic nervous system. AERP was measured by the extrastimulus method in the conscious dog with chronic atrioventricular block (n = 6) during the increasing and decreasing phases of an S1S2 fixed protocol. AERP was longer during the increasing phase than during the decreasing phase, thus demonstrating hysteresis, calculated as the difference between the two values. Hysteresis was greater with an S1S1 basic cycle length of 300 ms than with a basic cycle length of 400 ms, 9 +/- 0.9, and 7 +/- 0.9 ms, respectively. It was also greater with trains of six basic cycles before each extrastimulus S2 than with trains of 12 basic cycles, 9 +/- 0.9 and 7 +/- 1.0 ms, respectively. Suppression of vagal tone with atropine reduced hysteresis from 8 +/- 0.6 to 4 +/- 0.6 ms, whereas suppression of cardioaccelerator tone with propranolol increased it from 9 +/- 0.9 to 14 +/- 1.2 ms. These data were confirmed by the neostigmine-induced increase in hysteresis from 8 +/- 0.8 to 11 +/- 0.8 ms and the isoproterenol-ind...Continue Reading

References

Feb 18, 1992·European Journal of Pharmacology·M BoucherP Duchêne-Marullaz
Nov 1, 1991·Circulation Research·P LorenteJ Jalife
Apr 1, 1985·Journal of Pharmacological Methods·M Boucher, P Duchene-Marullaz
Apr 1, 1972·The International Journal of Neuroscience·A Katchalsky, E Neumann
Jan 1, 1984·The American Journal of Cardiology·M H LehmannM Akhtar
Jul 18, 1913·The Journal of Physiology·G R Mines

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Citations

Feb 1, 2008·Pacing and Clinical Electrophysiology : PACE·Xiufen QuYing Song
Nov 13, 2004·Physiological Measurement·Kityee Au-YeungPatrick D Wolf
Nov 27, 2020·Journal of the American Heart Association·Lianne N van Staveren, Natasja M S de Groot

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