Hysteresis in the cell response to time-dependent substrate stiffness.

Biophysical Journal
Achim Besser, Ulrich S Schwarz

Abstract

Mechanical cues like the rigidity of the substrate are main determinants for the decision-making of adherent cells. Here we use a mechano-chemical model to predict the cellular response to varying substrate stiffnesses. The model equations combine the mechanics of contractile actin filament bundles with a model for the Rho-signaling pathway triggered by forces at cell-matrix contacts. A bifurcation analysis of cellular contractility as a function of substrate stiffness reveals a bistable response, thus defining a lower threshold of stiffness, below which cells are not able to build up contractile forces, and an upper threshold of stiffness, above which cells are always in a strongly contracted state. Using the full dynamical model, we predict that rate-dependent hysteresis will occur in the cellular traction forces when cells are exposed to substrates of time-dependent stiffness.

References

Dec 2, 2004·Cell Motility and the Cytoskeleton·Tony YeungPaul A Janmey
Feb 7, 2009·Nature Reviews. Molecular Cell Biology·Benjamin GeigerAlexander D Bershadsky
May 30, 2009·Cell Motility and the Cytoskeleton·Paul A JanmeyQi Wen
Jun 27, 2009·Science·Dennis E DischerPeter W Zandstra
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Démosthène MitrossilisAtef Asnacios

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Citations

Jul 17, 2012·Journal of Cell Science·Ulrich S Schwarz, Margaret L Gardel
Jun 21, 2013·Biomechanics and Modeling in Mechanobiology·Carlos BorauJosé Manuel García-Aznar
Oct 6, 2016·Biophysical Journal·Guang-Kui XuHuajian Gao
Jul 7, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Achim BesserUlrich S Schwarz
Feb 7, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Tanny Lai, K-H Chiam
Dec 22, 2020·Annual Review of Condensed Matter Physics·Shiladitya BanerjeeUlrich S Schwarz
Jan 12, 2011·Journal of the American Chemical Society·Hiroshi Y YoshikawaMotomu Tanaka

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