PMID: 18411626Apr 17, 2008Paper

Hystologic and hemodynamic aspects of warm ischemic graft in relation to the preservation method

Actas urologicas españolas
R Cabello BenaventeE Lledó García

Abstract

The non-heart-beating donor has been proposed as a solution to donor shortage for renal transplantation. Because the nature of such donors, the kidneys so derived have been damaged by primary warm ischemia (WI), and so potentially they may never function. Minimizing graft injury is especially important in case of transplantation form marginal donors because of a high rate of delayed graft function or primary nonfunction. The aim of this experimental study is to assess the structural and hemodynamic consequences of hypothermic perfusion (HP) versus cold storage (CS), in renal allograft after a period of WI. We used 20 mini-pigs. WI was achieved by vascular pedicle occlusion during 45 min. We divided organs in 4 groups: A (n=5), kidneys with WI and then transplanted; group B (n=5), grafts with WI and implanted after HP with Belzer solution in our computerized perfusion system. Group C-control, (n=5) transplanted without WI and D (n=5) with WI and 60 min of CS in UW-Viaspan solution. All the procedure was recorded by a computerized data system. Renal vascular resistance (RVR) and renal vascular flow (RVF) were automatically calculated by means of mathematical formulas after renal transplantation. Subsequently histological study wa...Continue Reading

Related Concepts

Related Feeds

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

Related Papers

Actas urologicas españolas
E Lledó GarcíaJ F del Cañizo López
European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
B StoffelsR H Tolba
Transplant International : Official Journal of the European Society for Organ Transplantation
J H DaemenGauke Kootstra
© 2022 Meta ULC. All rights reserved