Hzf regulates adipogenesis through translational control of C/EBPalpha.

The EMBO Journal
Hiroyuki KawagishiMasataka Sugimoto

Abstract

Adipocyte differentiation requires a well-defined programme of gene expression in which the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein) has a central function. Here, we show that Hzf (haematopoietic zinc-finger), a previously identified p53 transcriptional target, regulates C/EBPalpha expression. Hzf is induced during differentiation of preadipocyte cell lines, and its suppression by short hairpin RNA disrupts adipogenesis. In Hzf's absence, expression of C/EBPalpha is severely impaired because of reduced translation of its mRNA. Hzf physically interacts with the 3' untranslated region of C/EBPalpha mRNA to enhance its translation. Taken together, these findings underscore a critical role of Hzf in the adipogenesis regulatory cascade.

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Citations

Oct 20, 2010·Molecular and Cellular Biology·Heather L ArmataHayla K Sluss
Mar 16, 2011·Molecular and Cellular Biology·Hideaki NakamuraMasataka Sugimoto
Mar 23, 2012·BMC Molecular Biology·Carolin Fromm-DorniedenBernhard G Baumgartner
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Apr 15, 2014·Journal of Lipid Research·Cristina M RamírezCarlos Fernández-Hernando
Sep 6, 2018·International Journal of Molecular Sciences·Jelena KrsticAndreas Prokesch

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