PMID: 6987651Jan 1, 1980Paper

I and i antigens of human peripheral blood lymphocytes cocap with receptors for concanavalin A

Proceedings of the National Academy of Sciences of the United States of America
Ten FeiziW J Yount

Abstract

Surface immunofluorescence experiments using a human anti-i and two anti-I antisera have been performed on human peripheral blood lymphocytes. These are known to contain cold-reactive monoclonal IgM antibodies against the carbohydrate sequence: (formula: see text). A high proportion of B- and T-type lymphocytes express these I and i determinants. In the presence of anti-human immunoglobulin, the cold-reactive membrane-associated complexes of I-anti-I and i-anti-i become stabilized, and redistribution (with patching and capping) can be elicited at 37 degrees C. Dual fluorescence experiments have shown striking concordant staining of I or i (fluorescein) caps and patches with concanavalin A (rhodamine) reactive sites on normal and leukemic cells, suggesting that a proportion of I and i active structures of lymphocyte membranes are structurally associated or physiologically coupled with glycoproteins carrying oligosaccharides with branched mannosyl cores.

References

Apr 28, 1978·Biochemical and Biophysical Research Communications·H NiemannS I Hakomori
Jul 1, 1978·Cancer·J O Moore, G L Logue
Sep 15, 1977·The New England Journal of Medicine·W Pruzanski, K H Shumak
Dec 1, 1965·American Journal of Physical Anthropology·A S WienerJ Davis

Citations

Aug 1, 1987·Archives of Biochemistry and Biophysics·H J AllenR DiCioccio
Jun 1, 1986·Immunological Investigations·H J Allen

Related Concepts

Surface Antigens
Immunofluorescence Assay
Immunologic Capping
Lymphoid Cells
Mannosides
Receptors, Concanavalin A

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