I-II loop structural determinants in the gating and surface expression of low voltage-activated calcium channels.

PloS One
Joel P BaumgartEdward Perez-Reyes

Abstract

The intracellular loops that interlink the four transmembrane domains of Ca(2+)- and Na(+)-channels (Ca(v), Na(v)) have critical roles in numerous forms of channel regulation. In particular, the intracellular loop that joins repeats I and II (I-II loop) in high voltage-activated (HVA) Ca(2+) channels possesses the binding site for Ca(v)beta subunits and plays significant roles in channel function, including trafficking the alpha(1) subunits of HVA channels to the plasma membrane and channel gating. Although there is considerable divergence in the primary sequence of the I-II loop of Ca(v)1/Ca(v)2 HVA channels and Ca(v)3 LVA/T-type channels, evidence for a regulatory role of the I-II loop in T-channel function has recently emerged for Ca(v)3.2 channels. In order to provide a comprehensive view of the role this intracellular region may play in the gating and surface expression in Ca(v)3 channels, we have performed a structure-function analysis of the I-II loop in Ca(v)3.1 and Ca(v)3.3 channels using selective deletion mutants. Here we show the first 60 amino acids of the loop (post IS6) are involved in Ca(v)3.1 and Ca(v)3.3 channel gating and kinetics, which establishes a conserved property of this locus for all Ca(v)3 channels. ...Continue Reading

References

Dec 1, 1993·Trends in Neurosciences·W A Catterall
Aug 11, 1998·Neuron·M J Berridge
Apr 4, 2000·Physiological Reviews·F Bezanilla
Apr 6, 2000·The Journal of Biological Chemistry·A MonteilJ Nargeot
Oct 14, 2000·Annual Review of Cell and Developmental Biology·W A Catterall
Feb 22, 2001·Trends in Neurosciences·S C Stotz, G W Zamponi
Nov 7, 2001·The Journal of General Physiology·C J FrazierS W Jones
Nov 17, 2001·The Journal of Physiology·R MarksteinerS Hering
Nov 6, 2002·FEBS Letters·L' LacinováF Hofmann
Dec 31, 2002·Physiological Reviews·Edward Perez-Reyes
May 14, 2003·The Journal of General Physiology·Karel TalaveraBernd Nilius
Jul 11, 2003·Nature·Joshua T WolfePaula Q Barrett
Mar 16, 2004·The Journal of Biological Chemistry·Jin-Yong ParkJung-Ha Lee
Jul 16, 2004·Journal of Neurophysiology·Janet MurbartiánEdward Perez-Reyes
Nov 9, 2004·Trends in Pharmacological Sciences·Mark W RichardsAnnette C Dolphin
May 13, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Iuliia VitkoEdward Perez-Reyes
Jun 15, 2005·Neuron·Heather L AglerDavid T Yue
Jul 1, 2005·FEBS Letters·Juan Manuel AriasEdward Perez-Reyes
Sep 1, 2005·Pflügers Archiv : European journal of physiology·Alice D LamDorothy A Hanck
Sep 7, 2006·Pflügers Archiv : European journal of physiology·Karel Talavera, Bernd Nilius
Nov 4, 2006·The Journal of Physiology·Achraf TraboulsiePhilippe Lory
Jan 12, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Iuliia VitkoEdward Perez-Reyes
Mar 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Miljen M JagodicSlobodan M Todorovic
Aug 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael T NelsonSlobodan M Todorovic
Nov 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael T NelsonSlobodan M Todorovic
Jan 26, 2008·The Journal of Biological Chemistry·Imilla I Arias-OlguínEdward Perez-Reyes
Dec 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Albert J BeckerHeinz Beck

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Citations

Dec 18, 2013·Pflügers Archiv : European journal of physiology·Edward Perez-Reyes, Jung-Ha Lee
Feb 12, 2014·Pflügers Archiv : European journal of physiology·A SenatoreJ D Spafford
Feb 23, 2011·Pflügers Archiv : European journal of physiology·Mária KarmažínováLubica Lacinová
Oct 4, 2011·Cellular and Molecular Life Sciences : CMLS·Brett A Simms, Gerald W Zamponi
Nov 28, 2013·The Journal of Physiology·Veit-Simon EckleEdward Perez-Reyes
Oct 22, 2015·Channels·Norbert Weiss, Lubica Lacinova
Aug 27, 2015·Pflügers Archiv : European journal of physiology·Mária KarmažínováĽubica Lacinová
Mar 31, 2015·Progress in Neurobiology·Felix NeumaierToni Schneider
Dec 17, 2008·Biochimica Et Biophysica Acta·Sylvaine HucPhilippe Lory
Oct 4, 2017·The Journal of Biological Chemistry·Jean CheminJ David Spafford
Nov 8, 2018·Channels·Bohumila Jurkovicova-TarabovaLubica Lacinova
Sep 10, 2010·Pflügers Archiv : European journal of physiology·Maria KarmazinovaLubica Lacinova
Feb 12, 2010·American Journal of Physiology. Cell Physiology·K A AromolaranE S Piedras-Rentería
Dec 2, 2011·The Journal of Biological Chemistry·Norbert WeissMichel De Waard
May 11, 2012·American Journal of Physiology. Cell Physiology·Merav MorYoram Etzion
Aug 24, 2013·The Journal of Biological Chemistry·Pierre-Olivier Demers-GirouxLucie Parent
Jun 21, 2019·Journal of Medical Genetics·Norbert Weiss, Gerald W Zamponi
Oct 3, 2018·Current Medicinal Chemistry·Dan WangRichard J Lewis
Feb 20, 2017·Neuronal Signaling·Norbert Weiss, Gerald W Zamponi
Nov 16, 2018·BMC Research Notes·Rogelio Arteaga-TlecuitlJuan Carlos Gomora
May 2, 2015·The Journal of Biological Chemistry·Arnaud MonteilPhilippe Lory

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Datasets Mentioned

BETA
AAF35287
AAM67414

Methods Mentioned

BETA
transfections
transfection
enzyme-linked immunosorbent assay

Software Mentioned

pCLAMP
Clampfit
Excel
Prism

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